Fig. 5.1 T cell activation requires recognition of the antigen and costimulatory signals. Inflammation generated by tissue damage or infections activates antigen-presenting cells (APCs) and stimulates the expression of costimulatory…
Disease DFTD CTVT Species affected Tasmanian devil Dog, wolf, coyote, jackals, foxes Distribution Tasmania Worldwide Age of origin About 18 years ago At least 6,000 years ago Likely cell of…
Fig. 21.1 Type I allergic reaction. B B cell, DC dendritic cell, eo eosinophilic granulocyte, IgE immune globulin E, IL interleukin, MC mast cell, Th2 T helper cell type 2,…
Marker Structure/function Ligand Effect of activation BDCA-2/BDCA-4 Associated with FcεRlγ to form a signaling receptor complex ITAM Upon ligation, they inhibit TLR activation and release of type I IFN CD4…
7. Miki C, Kusunoki M, Inoue Y, et al. Remodeling of the immunoinflammatory network system in elderly cancer patients: implications of inflamm-aging and tumor-specific hyperinflammation. Surg Today. 2008;38:873–8.PubMed 8. Vasto…
Gene Disease Inheritance Clinical features Pathogenesis Immune defects Associated cancers ATM (OMIM*607585) Ataxia-telangiectasia AR Cerebellar ataxia, oculocutaneous telangiectasia, chromosomal instability, radiosensitivity, thymic aplasia, recurrent sinopulmonary infections, cancer predisposition (up 40…
Fig. 14.1 Autophagy signaling pathway and antitumor therapeutic targets 14.2 Autophagy and Cancer The role of autophagy in cancer is rather perplexing. It is widely postulated that the autophagic pathway…
Fig. 7.1 IL-12 links innate and adaptive antitumor immunity. IL-12 utilizes several mechanisms to induce antitumor effects. IL-27 activates innate effectors, such as NK cells, NKT cells, and γδ −…
© Springer-Verlag Berlin Heidelberg 2015Nima Rezaei (ed.)Cancer Immunology10.1007/978-3-662-44006-3_16 16. Epigenetics and microRNAs in Cancer Petra M. Wise1, 2 , Kishore B. Challagundla1, 2 and Muller Fabbri1, 3 (1) Department of Pediatric Hematology/Oncology, Children’s Center for Cancer and Blood Diseases, Norris…
50. Allavena P, Sica A, Garlanda C, Mantovani A. The yin-yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev. 2008;222:155–61.PubMed 51. Bottazzi B, Polentarutti N, Acero R,…
