Estrogen and Progesterone Action
FIGURE 127-1. Activation of steroid receptors. In the absence of ligand, steroid receptors (SR) reside in an inactive complex containing heat shock proteins (HSP) and other proteins. Upon steroid binding,…
Applications of Genetics in Endocrinology
FIGURE 7-1. Genes and polymorphic marker density of chromosome 8. The relative numbers of genes and SNPs are shown above chromosome 8. The microsatellite markers (short tandem repeats, STRs) and…
Pancreatic and Islet Transplantation
FIGURE 50-1. Combined pancreas and kidney transplant. Digestive juices of the pancreas are drained into the intestine via an enteric anastomosis between the donor duodenum and the recipient ileum. Venous…
Insulin-Like Growth Factor-1 and Its Binding Proteins
FIGURE 24-1. Structure of the human insulin-like growth factor 1 (IGF1) gene and the precursor proteins it encodes. The black boxes that are shown represent exons. The portions of each…
Endometriosis
FIGURE 130-1. A, 10% hematoxylin and eosin stain of a peritoneal lesion of endometriosis. Note the presence of glands and stroma surrounded by fibrosis. B, 10% hematoxylin and eosin stain…
Obesity: The Problem and Its Management
Using the definitions in Table 28-1, the prevalence of obesity in U.S. adults doubled between 1980 and 2002.8 Findings from the most recent National Health and Nutrition Examination Survey (NHANES…
Hereditary Disorders of the Skeleton
FIGURE 67-1. Osteopetrosis. This teenage girl with Albers-Schönberg disease has a “rugger-jersey” spine typical of adult (“benign”) osteopetrosis. The vertebral end plates are markedly thickened. Skeletal scintigraphy reveals fractures and…
Lipoprotein Metabolism and the Treatment of Lipid Disorders
FIGURE 42-1. The upper panel of the figure lists the density range that encompasses each lipoprotein class and the major tissue in which the lipoprotein is synthesized. The bottom panel…
Endocrinology: Impact on Science and Medicine
FIGURE 1-1. Timeline of selected advances in endocrinology. (ATDs, Antithyroid drugs; CAH, congenital adrenal hyperplasia; DA, dopamine; I-, iodine; OCPs, oral contraceptive pills; Pheo, pheocromocytoma; RAI, radioactive iodine; Rx, treatment;…
Paget’s Disease of Bone
FIGURE 71-1. Radiograph demonstrating osteoporosis circumscripta of the skull affecting the frontal and temporal regions. FIGURE 71-2. Radiograph of an osteolytic lesion of Paget’s disease that began in the diaphysis…
