Pathophysiology and Treatment of Dyslipidemia in Diabetes Sherita Hill Golden Miguel Munoz Atherosclerosis is the leading cause of death among individuals with diabetes, accounting for 80% of all mortality. Approximately…
Disorders of HDL Metabolism Scott M. Lilly Daniel J. Rader Observational and epidemiologic studies have strongly implicated a low level of high-density lipoprotein cholesterol (HDL-C) as an independent risk factor…
Disorders of LDL Metabolism Peter O. Kwiterovich Jr. Peter J. Espenshade Almost 100 years have passed since the classic experiments of Anitschkow and Chalatow (see Ref. 1 for review) who…
Disorders of Hypertriglyceridemia Michael A. Miller In 1959, Drs. Albrink and Mann reported the first association between elevated triglycerides (TG) and cardiovascular disease (CVD) (1). Subsequent case-control and longitudinal studies…
Use of Noninvasive Methods to Diagnose Cardiovascular Disease in Dyslipidemic Patients Ilan Gottlieb João A.C. Lima The effect of higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C)…
Clinical Trial Evidence for Treatment of Dyslipidemia in the Prevention of Cardiovascular Disease Thomas A. Pearson Randomized trials with well-defined clinical end points provide the strongest proof that a purported…
Pathophysiology and Vascular Biology of Atherosclerosis Subroto Chatterjee Over 50 years ago, Dr. Alfred Blalock, a cardiovascular surgeon at the Johns Hopkins Hospital commented, “The heart is an innocent bystander…
Measurement of Lipids, Lipoproteins, and Apolipoproteins Paul S. Bachorik The concentrations of the plasma lipoproteins strongly predict the development of cardiovascular disease (CVD) and are used to evaluate the dyslipoproteinemias…
Pathogenesis of Atherosclerosis and the Unstable Plaque Frank D. Kolodgie Gaku Nakazawa Aya Nakazawa David R. Fowler Robert Kutys Renu Virmani The earliest descriptions of atherosclerotic lesions focused on morphologies…
Lipid, Apolipoprotein, and Lipoprotein Metabolism: Implications for the Diagnosis and Treatment of Dyslipidemia Peter O. Kwiterovich Jr. Human plasma lipoprotein metabolism is complex. An understanding of normal lipid, apolipoprotein, and…
