Oncohema Key

Clinical criteria (one or more)  Vascular thrombosis: One or more objectively confirmed episodes of arterial, venous or small vessel thrombosis occurring in any tissue or organ  Pregnancy morbidity:   One or…

Fig. 7.1 Implantation spectrum Pregnancy itself is a prothrombotic state – characterized by an increase in the levels of pro-coagulant factors, a simultaneous decrease in the levels of anticoagulant proteins,…

Age Greater parity Smoking Cardiovascular disease including:  Hypertension  Patent foramen ovale  Metallic heart valve Renal disease Migraine with aura Heritable thrombophilia Acquired thrombophilia: antiphospholipid syndrome Hyperhomocystinemia Hematological disorders  Thrombotic microangiopathies…

Fig. 2.1 Coagulation mechanism and targets for action of different anticoagulants. UFH unfractionated heparin, AT antithrombin, LMWH low-molecular-weight heparin The amount of activated factor X is further enhanced by the…

Heritable thrombophilia Possible heritable component Acquired risk factors for venous thrombosis Antithrombin deficiency High factor VIII/VWF Increasing age (over 35 in pregnancy) Protein C deficiency High factor IX Pregnancy Protein…

© Springer-Verlag London 2015Hannah Cohen and Patrick O’Brien (eds.)Disorders of Thrombosis and Hemostasis in Pregnancy10.1007/978-3-319-15120-5_1 1. Hemostatic Changes in Normal Pregnancy Carolyn M. Millar1   and Michael Laffan1   (1) Centre for Haematology, Faculty of Medicine, Hammersmith Campus, Imperial College,…