Time between drug administration and neuraxial puncture, catheter manipulation or withdrawal Time between neuraxial puncture, catheter manipulation or withdrawal and drug administration Laboratory tests ESA ASRA ESA ASRA Unfractionated…
Condition Fetal Alloimmune Congenital infection (e.g. CMV, toxoplasma, rubella, HIV) Aneuploidy (e.g. trisomies 13, 18, 21) Autoimmune (e.g. ITP, SLE) Severe rhesus hemolytic disease Inherited (e.g. Wiskott-Aldrich syndrome) Early-onset…
17. Rahimy MC, Gangbo A, Adjou R, Deguenon C, Goussanou S, Alihonou E. Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting. Blood….
Primary features Pathophysiology Complications Treatment DIC Abnormal coagulation (increased PT, APTT, reduced fibrinogen and platelets) Underlying precipitant, e.g. placental abruption, sepsis Excessive bleeding or thrombosis Treat the underlying cause…
Author and year HPA-1a (%) HPA-1b (%) HPA-3a (%) HPA-5a (%) HPA-5b (%) HPA-15 (%) HPA-1a & HPA-5b (%) Other (%) Reznikoff-Etievant (1988) [23] 90 Mueller-Eckhardt et al. (1989) [24]…
Variable GT ITP Gestational age at diagnosis (weeks) 32.8 ± 7.6 20.1 ± 11.1 Gestational age when platelet count counts at nadir (weeks) 35.7 ± 5.5 27.0 ± 11.2 Platelet count at diagnosis (×109/L) 71.3 ± 19.2 40.0 ± 25.5 Platelet count…
Maternal age over 40 years Multiparity Previous Cesarean section Uterine scarring (previous myomectomy, uterine curettage) Previous spontaneous or induced miscarriage Cigarette smoking and use of drugs such as cocaine Multiple…
Severe phenotype platelet function disorders Severe Glanzmann thrombasthenia Severe Bernard-Soulier syndrome Non-severe phenotype disorders Defects in platelet aggregation or adhesion Rare Glanzmann thrombasthenia variants (type II) Rare Bernard-Soulier syndrome variants…
Fig. 12.1 Prevalence of RBDs according to WFH 2011 survey (www.wfh.org) (closed bars) and EN-RBD (www.rbdd.eu) (open bars) 12.2 Classification of RBDs Most RBDs are expressed phenotypically as a parallel…
History Previous pre-eclampsia Chronic hypertension Renal disease Type 1 or type 2 diabetes Multiple pregnancy Family history of pre-eclampsia Antiphospholipid syndrome Chronic autoimmune disease Increasing maternal age beyond 34 years…
