The Cancer Genome
The Cancer Genome Yardena Samuels Alberto Bardelli Jared J. Gartner Carlos López-Otin INTRODUCTION There is a broad consensus that cancer is, in essence, a genetic disease, and that accumulation of…
Topoisomerase Interactive Agents
Topoisomerase Interactive Agents Khanh T. Do Shivaani Kummar James H. Doroshow Yves Pommier CLASSIFICATION, BIOCHEMICAL, AND BIOLOGIC FUNCTIONS OF TOPOISOMERASES Nucleic acids (DNA and RNA) being long polymers, topoisomerases fulfill…
Alkylating Agents
Alkylating Agents Kenneth D. Tew PERSPECTIVES Alkylating agents were the first anticancer molecules developed, and they are still used today. After more than 50 years of use, the basic chemistry…
Cutaneous Melanoma
Cutaneous Melanoma Antoni Ribas Craig L. Slingluff Jr. Steven A. Rosenberg INTRODUCTION Melanoma arises from the malignant transformation of the melanocyte, the cell responsible for the production of the pigment…
Genetic Testing in Skin Cancer
Genetic Testing in Skin Cancer Michele Gabree Meredith L. Seidel INTRODUCTION Many hereditary cancer predisposition syndromes are associated with cutaneous findings. Identification of unique dermatologic features provides an opportunity to…
Molecular Biology of Cutaneous Melanoma
Molecular Biology of Cutaneous Melanoma Michael A. Davies Levi A. Garraway INTRODUCTION The most common forms of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. While melanoma…
Cancer of the Skin
Cancer of the Skin Sean R. Christensen David J. Leffell INTRODUCTION One in five Americans will develop nonmelanoma skin cancer (NMSC) during his or her lifetime. NMSC is the most…
Genetic Counseling
Genetic Counseling Ellen T. Matloff Danielle C. Bonadies INTRODUCTION Clinically based genetic testing has evolved from an uncommon analysis ordered for the rare hereditary cancer family to a widely available…
Cancer Screening
Cancer Screening Otis W. Brawley Howard L. Parnes INTRODUCTION Cancer screening refers to a test or examination performed on an asymptomatic individual. The goal is not simply to find cancer…
Cancer Risk-Reducing Agents
Cancer Risk-Reducing Agents Dean E. Brenner Scott M. Lippman Susan T. Mayne WHY CANCER PREVENTION AS A CLINICAL ONCOLOGY DISCIPLINE Until recently, clinical oncology has been defined as a medical…
