Neoadjuvant Chemotherapy and Radiotherapy
Abstract Neoadjuvant chemotherapy (NACT) for breast cancer is the administration of systemic therapy to patients before surgery. It was initially used to downstage inoperable tumors but over time has become…
Management of the Intact Breast Primary in the Setting of Metastatic Disease
Abstract Due to advancements in diagnostic and multimodality therapy, patients with stage IV breast cancer can achieve long-term survival. For women with asymptomatic primary tumors, the mainstay of therapy remains…
Management of Bone Metastases in Breast Cancer
Abstract Managing patients with bone metastases requires a multidisciplinary approach applying the expertise of orthopedic surgeons, radiation oncologists, medical oncologists, and radiologists. Small lesions can usually be successfully treated with…
Detection and Clinical Implications of Occult Systemic Micrometastatic Breast Cancer
Abstract Distant metastasis is the leading cause of tumor-related death from breast cancer. Hematogenous dissemination of tumor cells from the primary tumor to distant sites cannot be detected by standard…
Inflammatory Breast Cancer
Abstract Inflammatory breast cancer (IBC) causes 7% of breast cancer deaths. The diagnosis is clinical (erythema, edema, peau d’orange involving at least one-third of the breast surface area). IBC is…
Surgical Procedures for Advanced Local and Regional Malignancies of the Breast
Abstract Surgery remains an integral part of the therapeutic plan for locally advanced breast cancer. Advances in systemic therapies have transformed the role of surgery for this population of patients…
Locally Advanced Breast Cancer
Abstract Locally advanced breast cancer (LABC) encompasses a wide range of breast tumors with poor prognosis, and multidisciplinary approach remains the cornerstone for the treatment of this difficult problem. Neoadjuvant…
Principles of Preoperative Therapy for Operable Breast Cancer
Abstract In clinical practice, the use of preoperative or neoadjuvant chemotherapy for the treatment of inoperable and operable breast cancer is currently well established. Once reserved for the treatment of…
Locoregional Recurrence After Mastectomy
Abstract Mastectomy surgery has been historically judged by its success at preventing local failures after primary invasive breast cancer treatment. Advancements in the use of adjuvant systemic treatments have further…
Solitary Metastases
Abstract Over the past 30 years, new and advanced breast cancer multimodality treatments have resulted in improved median survival times for patients with metastatic breast cancer. Breast cancer most commonly…
