ABNORMAL SECRETION OF GROWTH HORMONE
ABNORMAL SECRETION OF GROWTH HORMONE Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ DEFICIENCY OF GROWTH HORMONE GH deficiency results from various causes, and the clinical manifestations depend…
MEASUREMENT OF PLASMA GROWTH HORMONE
MEASUREMENT OF PLASMA GROWTH HORMONE Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ The measurement of GH in blood is problematic because of the heterogeneous nature of GH….
ACTIONS OF GROWTH HORMONE
ACTIONS OF GROWTH HORMONE Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ Growth hormone has numerous biologic actions, many occurring in concert to enhance protein anabolism and tissue…
REGULATION OF THE GROWTH HORMONE RECEPTOR AND BINDING PROTEIN
REGULATION OF THE GROWTH HORMONE RECEPTOR AND BINDING PROTEIN Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ For reasons of accessibility, little is known about the regulation of…
SOMATOTROPE DEVELOPMENT AND GROWTH HORMONE
SOMATOTROPE DEVELOPMENT AND GROWTH HORMONE Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ Several pituitary transcription factors are involved in pituitary somatotrope development. Their consideration is important here…
GROWTH HORMONE–BINDING PROTEIN
GROWTH HORMONE–BINDING PROTEIN Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ The GHBP is the soluble, extracellular domain of the GHR. In humans and many other species, the…
GROWTH HORMONE RECEPTOR
GROWTH HORMONE RECEPTOR Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ The GH receptor (GHR) is a 620-amino-acid, ˜130 kDa, single-chain glycoprotein with a single transmembrane domain, a…
GROWTH HORMONE STRUCTURE
GROWTH HORMONE STRUCTURE Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ Human GH is heterogeneous and consists of several molecular variants (Fig. 12-2).2 The principal form is a…
GROWTH HORMONE GENES
GROWTH HORMONE GENES Part of “CHAPTER 12 – GROWTH HORMONE AND ITS DISORDERS“ In humans, GH is encoded by two genes on the long arm of chromosome 17.1 They are…
