SECONDARY HYPERALDOSTERONISM
SECONDARY HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ A variety of disorders of the kidney, heart, liver, and gastrointestinal tract may lead to hyperreninemia and, in turn, to hyperaldosteronism and…
SYNDROMES OF REAL OR APPARENT MINERALOCORTICOID EXCESS NOT CAUSED BY ALDOSTERONE
SYNDROMES OF REAL OR APPARENT MINERALOCORTICOID EXCESS NOT CAUSED BY ALDOSTERONE Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Occasionally, patients may have features of mineralocorticoid excess (hypokalemic…
ADRENOCORTICAL CARCINOMA
ADRENOCORTICAL CARCINOMA Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Adrenocortical carcinoma is an extremely rare cause of hyperal-dosteronism and accounts for fewer than 2% of aldosterone-producing tumors.52,52a…
DEXAMETHASONE-SUPPRESSIBLE HYPERALDOSTERONISM
DEXAMETHASONE-SUPPRESSIBLE HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Dexamethasone-suppressible hyperaldosteronism (glucocorticoid-remediable aldosteronism) is a rare familial disorder inherited as an autosomal-dominant trait that exhibits the clinical…
IDIOPATHIC HYPERALDOSTERONISM
IDIOPATHIC HYPERALDOSTERONISM Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Idiopathic bilateral adrenocortical hyperplasia of the zona glomerulosa (idiopathic hyperaldosteronism) is characterized by features similar to those associated…
ALDOSTERONE-PRODUCING ADENOMAS
ALDOSTERONE-PRODUCING ADENOMAS Part of “CHAPTER 80 – HYPERALDOSTERONISM“ CLINICAL FEATURES AND PATHOPHYSIOLOGY Aldosterone-producing adrenocortical adenomas usually are small (0.5–2.5 cm), unilateral, solitary, and associated with hypoplastic zona glomerulosa. Occasionally, however,…
“PRIMARY ALDOSTERONISM”
“PRIMARY ALDOSTERONISM” Part of “CHAPTER 80 – HYPERALDOSTERONISM“ Autonomous overproduction of aldosterone occurs in ˜2% of patients with hypertension and was recognized initially as being associated with either a unilateral…
PHYSIOLOGY OF ALDOSTERONE
PHYSIOLOGY OF ALDOSTERONE Part of “CHAPTER 80 – HYPERALDOSTERONISM“ SYNTHESIS The zona glomerulosa cells of the adrenal cortex synthesize aldosterone from corticosterone in a two-step, mixed function oxidation reaction that…
DISORDERS OF MINERALOCORTICOID EXCESS
DISORDERS OF MINERALOCORTICOID EXCESS Part of “CHAPTER 80 – HYPERALDOSTERONISM“ Mineralocorticoid excess, whether primary or secondary, and disorders that mimic it are commonly manifested clinically as hypokalemia, which usually but…
HYPERALDOSTERONISM
HYPERALDOSTERONISM John R. Gill JR. DISORDERS OF MINERALOCORTICOID EXCESS PHYSIOLOGY OF ALDOSTERONE “PRIMARY ALDOSTERONISM” ALDOSTERONE-PRODUCING ADENOMAS Related posts: FUTURE PROSPECTS HEIGHT AND WEIGHT REGULATION OF THE GROWTH HORMONE RECEPTOR AND…
