Mature leukemias • T-cell prolymphocytic leukemia • T-cell large granular lymphocytic leukemia • Chronic lymphoproliferative disorders of NK-cells • Aggressive NK-cell leukemia • Adult T-cell leukemia/lymphoma • Sezary syndrome Mature…
Fig. 1 A Performance of the Lymph2Cx assay using an abbreviated gene set (20 genes) compared to the “gold standard method” of previously reported GEP as well as three IHC-based algorithms…
Prognostic group # risk factorsa Low risk 0, 1 Low intermediate 2 High intermediate 3 High 4, 5 aelevated LDH, advanced stage (Ann Arbor III/IV), age > 60, ≥ 2 extralymphatic sites of involvement…
Fig. 1 a Kaplan–Meier curve showing progressive improvement in the overall survival of FL patients over time. b Patients diagnosed and treated in post-rituximab era-2 (light color) had a statistically significant…
Fig. 1 Incidence Rates of NHL subtypes in the USA, 2000–2011, Surveillance, Epidemiology, and End-Results Program (Surveillance Research Program, National Cancer Institute SEER*Stat software (www.seer.cancer.gov/seerstat), Version 8.1.5. Surveillance, Epidemiology, and End…
IgM monoclonal gammopathy of any concentration Bone marrow infiltration by small lymphocytes showing plasmacytic differentiation Intertrabecular pattern of bone marrow infiltration Surface IgM+, CD19+, CD20+, CD22+, CD25+. CD27+, FMC7+, CD5±,…
1 No uptake 2 Uptake ≤ mediastinum 3 Uptake > mediastinum but ≤ liver 4 Uptake moderately higher than liver 5 Uptake markedly higher than liver and/or new lesions X New areas of uptake unlikely to…
Fig. 1 The histopathology of PTLD. a Infectious mononucleosis-like “early” PTLD lesion. b Monomorphic PTLD, Burkitt lymphoma type. c Polymorphic PTLD. d Positive EBV in situ hybridization stain in a PTLD…
Site Procedure Gastric MALT lymphoma Stomach • Endoscopic ultrasound • H. pylori status (by IHC)a • FISH or molecular assay for the t(11;18) translocation Non-gastric MALT lymphoma Breast • Mammography…
Clinical Stage Absolute lymphocyte count Lymphocyte doubling time Bone marrow infiltration pattern Treatment response Age Performance status Genetic IGHV mutational status FISH Low risk: del(13q) Intermediate risk: trisomy 12 High…
