Glucose-6-Phosphate Dehydrogenase Deficiency
Chapter Outline G6PD IN RED BLOOD CELL METABOLISM Structure and Biochemistry of G6PD Genetics of G6PD Features of G6PD in Red Blood Cells Molecular Basis of G6PD Deficiency Epidemiology of…
Paroxysmal Nocturnal Hemoglobinuria
Chapter Outline HISTORY EPIDEMIOLOGY MOLECULAR PATHOGENESIS Paroxysmal Nocturnal Hemoglobinuria and Complement Decay Accelerating Factor Membrane Inhibitor of Reactive Lysis Inherited Mutations of CD55 and CD59 Congenital Abnormalities of Genes Involved…
Disorders of Iron and Copper Metabolism, the Sideroblastic Anemias, and Lead Toxicity
Chapter Outline PHYSIOLOGIC CHEMISTRY OF IRON Iron and Oxidation Iron-Protein Complexes Iron Toxicity ACQUISITION AND DISTRIBUTION OF IRON Iron Absorption Intercellular Iron Transport Intracellular Iron Metabolism ROLE OF IRON IN…
Pyruvate Kinase Deficiency and Disorders of Glycolysis
Chapter Outline HEXOKINASE DEFICIENCY Clinical Manifestations Biochemistry Genetics Therapy GLUCOSE PHOSPHATE ISOMERASE DEFICIENCY Clinical Manifestations Biochemistry Genetics and Inheritance Therapy PHOSPHOFRUCTOKINASE DEFICIENCY Clinical Manifestations Biochemistry Genetics and Inheritance Therapy ALDOLASE…
Autoimmune Hemolytic Anemia
Chapter Outline PRIMARY AUTOIMMUNE HEMOLYTIC ANEMIA Incidence Natural History Clinical Manifestations Routine Laboratory Evaluation Serologic Laboratory Evaluation Differential Diagnosis Characteristics of Erythrocyte Autoantibodies Therapy Pathogenesis of Autoantibody Formation SECONDARY AUTOIMMUNE…
Neonatal Jaundice and Disorders of Bilirubin Metabolism
Chapter Outline INTRODUCTION BILIRUBIN METABOLISM Bilirubin Production and Transport Hepatic Uptake of Bilirubin Bilirubin Conjugation Bilirubin Excretion Enterohepatic Circulation of Bilirubin DIAGNOSIS OF HYPERBILIRUBINEMIA Total Serum Bilirubin Measurements Transcutaneous Bilirubinometry…
Megaloblastic Anemia
Chapter Outline DEFINITIONS HISTORY FOLATE Chemistry of Folates Folate Sources, Requirements, and Stores Physiology of Folates Biochemistry of Folates COBALAMIN (VITAMIN B 12 ) Chemistry of Cobalamins Cobalamin Sources, Requirements,…
Diagnostic Approach to the Anemic Patient
Chapter Outline INTRODUCTION DEFINITION OF ANEMIA CLASSIFICATION OF ANEMIAS EVALUATION OF THE ANEMIC PATIENT Initial Encounter Selection of Appropriate Laboratory Tests Automated Cell Counting The Blood Film Introduction In this…
Principles of Bone Marrow and Stem Cell Transplantation
Chapter Outline HISTORY AND OVERVIEW CONDITIONING REGIMENS SOURCES OF STEM CELLS Allogeneic Stem Cell Transplantation Autologous Stem Cell Transplantation PERITRANSPLANT SUPPORTIVE CARE Transfusion Support Nutrition Support Infection Prophylaxis and Treatment…
Anatomy and Physiology of Hematopoiesis
Chapter Outline HISTORY PHYLOGENY MARROW ANATOMY HEMATOPOIETIC CELLS Stem Cells Progenitor Cells Precursors and Mature Cells THE HEMATOPOIETIC GROWTH FACTORS The Lymphohematopoietic Cytokines The Receptor Tyrosine Kinase Ligands The Interleukin…
