Anticoagulant Mode of action Plasma half-life Monitoring test(s) Therapeutic range Reversal Notes Warfarin (vitamin K antagonists) Interference with post-translational γ-carboxylation of vitamin K-dependent clotting factors 20–60 h INR 2.0–3.0, moderate…
Fig. 4.1 Example of a validation checklist 4.3 Validation Studies In the hemostasis laboratory, validation studies encompass the establishment of analytical performance expectations; calibration and calibration verification; determination of quality…
Fig. 5.1 Platelet satellitism and platelet clumping in a blood smear from a patient with EDTA-pseudothrombocytopenia (Courtesy Sherrie L. Perkins, MD, University of Utah Medical Center [Wright’s stain, oil immersion])…
Fig. 9.1 Regulation of thrombin activity by vascular endothelium. The effects of major antithrombotic properties of the blood vessel wall are shown. Regulation of thrombin activity is important because thrombin…
Disorders associated with: Thrombocytopenia Platelet dysfunction (qualitative platelet disorders) Coagulation disorders Autosomal recessive Autosomal recessive X-linked Bernard-Soulier syndrome Bernard-Soulier syndrome Factor VIII deficiency (hemophilia A) Congenital amegakaryocytic thrombocytopenia Glanzmann’s thrombasthenia…
Fibrinogen deficient curve % Activity Fibrinogen, mg/dL PT (s) (normal 10.7–15.0 s) PTT (s) (normal 25–40 s) 100 288 11 28 80 230.4 11.4 29.8 70 201.6 11.6 29.8 40…
CYP2C9 VKORC1 *1/*1 *1/*2 *1/*3 *2/*2 *2/*3 *3/*3 GG Typical Typical Moderate ↓ Moderate ↓ Moderate ↓ Significant ↓ AG Typical Moderate ↓ Moderate ↓ Moderate ↓ Significant ↓ Significant…
Fig. 8.1 Generation of cross-linked fibrin by thrombin and factor XIIIa following activation of coagulation, and consequences of plasmin degradation of cross-linked fibrin. (a) Following activation of coagulation, thrombin activates…
Hematocrit, % Blood volume (excluding citrate), mL 4.5 2.7 1.8 0.9 56 0.41 0.24 0.16 0.08 57 0.40 0.24 0.16 0.08 58 0.39 0.23 0.16 0.08 59 0.38 0.23 0.15…
8. Kunz D, Kunz WS, Scott CS, et al. Automated CD61 immunoplatelet analysis of thrombocytopenic samples. Br J Haematol. 2001;112:584–92.PubMedCrossRef 9. De la Salle BJ, McTaggart PN, Briggs C, et…
