Differential Diagnosis of Thrombocytopenia Joel S. Bennett Charles S. Abrams Thrombocytopenia is encountered frequently in clinical practice, engendering substantial and appropriate concern about its etiology and the consequent risk and…
Overview of Acquired and Inherited Clinical Platelet Disorders Joel S. Bennett An insufficient number of platelets (thrombocytopenia) or impaired platelet function (thrombocytopathia) can produce bleeding. Both situations are encountered frequently…
Laboratory Markers of Activated Coagulation and Its Regulation Kenneth A. Bauer Helen A. Ireland The development of blood tests to predict thrombotic events, or to confirm or exclude the presence…
Acquired Disorders of Coagulation: The Immune Coagulopathies Charles R.M. Hay The formation of a blood clot is the final result of a cascade of interactions among multiple plasma proteins that…
Clinical Disorders of Fibrinolysis Daphne B. Stewart Charles W. Francis Victor J. Marder Excessive promotion or inhibition of fibrinolysis interferes with the hemostatic balance and can lead to clinical bleeding…
Familial Multiple Coagulation Factor Deficiencies Bin Zhang David Ginsburg The familial multiple coagulation factor deficiencies (FMFDs) are a group of rare inherited disorders characterized by a simultaneous decrease in the…
Afibrinogenemias and Dysfibrinogenemias Dennis K. Galanakis Congenital fibrinogen disorders have provided novel insights into structure/function relationships and into the central role of fibrinogen in hemostasis. They are generally classified as…
Rare Inherited Coagulation Disorders Other than Hemophilia Pier Mannuccio Mannucci Flora Peyvandi Massimo Franchini The rare inherited coagulation disorders (RICDs), usually transmitted in an autosomal recessive fashion, represent 3% to…
von Willebrand Disease: Diagnosis, Classification, and Treatment J. Evan Sadler David Lillicrap von Willebrand disease (vWD) was discovered by Erik von Willebrand,1,2 a Finnish internist who investigated a family living…
Clinical Manifestations and Therapy of Inherited and Acquired Hemophilia Edward G.D. Tuddenham Peter W. Collins T. T. Yee HISTORICAL INTRODUCTION Knowledge of a congenital bleeding disorder affecting male infants can…
