Hereditary Hemorrhagic Telangiectasia Michelle Letarte Claire L. Shovlin Hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, was first recognized as a genetic disorder in the 19th century. HHT is…
Disorders of Connective Tissue and Extracellular Matrix Fransiska Malfait Anne De Paepe THE CONNECTIVE TISSUE AND THE EXTRACELLULAR MATRIX The connective tissue is the most abundant tissue throughout the body…
Overview of Primary Disorders of Blood Vessels William C. Aird The cardiovascular system consists of a closed system or arteries, arterioles, capillaries, venules, and veins, in addition to an open…
Laboratory Markers of Platelet Activation Paul Harrison Alan D. Michelson Prevention of platelet activation in the intact circulation is normally controlled by the antithrombotic nature of the endothelial cell surface,…
Acquired Disorders of Platelet Function A. Koneti Rao Joel S. Bennett Platelets are essential for normal hemostasis. Thus, defects in platelet function may lead to bleeding diatheses. Platelet function defects…
Inherited Disorders of Platelet Function Joel S. Bennett A. Koneti Rao Prolongation of the bleeding time in a patient with a normal platelet count suggests the presence of either von…
Acquired Nonimmune Thrombocytopenia Andreas Greinacher Theodore E. Warkentin Acquired thrombocytopenic disorders can be divided into five categories, plus the spurious entity of pseudothrombocytopenia (Table 64.1): hemodilution, sequestration (usually due to…
Inherited Thrombocytopenias Paquita Nurden Alan T. Nurden Bleeding syndromes arising from an inherited defect of platelet production are an important group of rare diseases with a variety of causes.1,2,3,4 Some,…
Drug-Induced Thrombocytopenia Richard H. Aster James N. George BACKGROUND Drugs induce thrombocytopenia through various mechanisms. The inhibition of platelet production is an expected result of the dose-dependent toxicity of chemotherapeutic…
Immune Thrombocytopenia and Posttransfusion Purpura Howard A. Liebman Douglas B. Cines James B. Bussel IMMUNE THROMBOCYTOPENIA Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by thrombocytopenia with or without…
