Antiplatelet Therapy
Antiplatelet Therapy Carlo Patrono As reviewed in other chapters, platelet activation and aggregation play a key role in atherothrombosis.1 Antiplatelet drugs target enzymes or receptors involved in the platelet synthesis…
New Antithrombotic Drugs
New Antithrombotic Drugs Jeffrey I. Weitz Peter L. Gross Currently available antithrombotic drugs include (a) antiplatelet agents, which inhibit platelet activation or aggregation, (b) anticoagulants, which attenuate fibrin formation, and…
Coumarin-Induced Skin Necrosis and Venous Limb Gangrene
Coumarin-Induced Skin Necrosis and Venous Limb Gangrene Theodore E. Warkentin Thrombotic events that result from coumarin administration are incongruous but well-documented complications of anticoagulant therapy. The key role of coumarin…
Hemorrhagic Complications of Anticoagulation
Hemorrhagic Complications of Anticoagulation Sam Schulman Mark A. Crowther Bleeding is the most common complication of anticoagulant therapy. The spectrum is from seemingly harmless subcutaneous ecchymoses, albeit cosmetically disturbing for…
Vitamin K Antagonists: Biochemistry, Pharmacology, and Management
Vitamin K Antagonists: Biochemistry, Pharmacology, and Management Nirmish Shah Thomas L. Ortel Sam Schulman INTRODUCTION/HISTORY Vitamin K antagonists (VKAs) are currently the most common oral anticoagulants used worldwide. The discovery…
Pharmacology and Mode of Action of Heparin and Glycosaminoglycans
Pharmacology and Mode of Action of Heparin and Glycosaminoglycans Meyer Michel Samama Jeanine M. Walenga Evi Kalodiki Jawed Fareed Heparin belongs to a class of linear acidic polysaccharides known as…
Overview of Therapeutic Agents Used in Thrombotic Disorders
Overview of Therapeutic Agents Used in Thrombotic Disorders Sam Schulman Victor J. Marder In this section, the many recent developments in drug and device therapy for venous or arterial thromboembolism…
Thrombotic and Hemorrhagic Complications Associated With Stem Cell Transplantation
Thrombotic and Hemorrhagic Complications Associated With Stem Cell Transplantation Yona Nadir Benjamin Brenner Thrombotic and hemorrhagic complications are common in stem cell transplantation (SCT) recipients. Endothelial cell (EC) injury is…
Myeloproliferative Neoplasms and Thrombohemorrhagic Complications
Myeloproliferative Neoplasms and Thrombohemorrhagic Complications Ayalew Tefferi The term “myeloproliferative disorder” (MPD) was first introduced by Dameshek1 in 1951 to emphasize the clinicopathologic interrelationship between essential thrombocythemia (ET), polycythemia vera…
The Antiphospholipid Syndrome
The Antiphospholipid Syndrome Jacob H. Rand Lucia R. Wolgast HISTORICAL BACKGROUND The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition that is defined by a constellation of clinical and laboratory…
