Inhibitors of Fibrinolysis
Inhibitors of Fibrinolysis BjÖRn Wiman Anna ÅGren The fibrinolytic system has many different functions in vivo. Within the blood vessels, its main function is to remove fibrin deposits and keep…
Plasminogen Activation and Regulation of Fibrinolysis
Plasminogen Activation and Regulation of Fibrinolysis Nicola J. Mutch Nuala A. Booth Hemostasis requires mechanisms both to stop bleeding by formation of a hemostatic plug and to dissolve this plug…
Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways
Protein C, Protein S, Thrombomodulin, and the Endothelial Protein C Receptor Pathways Laurent O. Mosnier John H. Griffin THE PROTEIN C PATHWAYS—OVERVIEW Control of coagulation reactions is essential for normal…
Antithrombin and the Serpin Family
Antithrombin and the Serpin Family Susan C. Bock ANTITHROMBIN III Overview Antithrombin III (ATIII) is a plasma proteinase inhibitor that inactivates thrombin and the enzymes responsible for the generation of…
Factor XIII
Factor XIII CéDric Duval Helen Phiuppou Robert A.S. AriëNs Factor XIII (FXIII) is an unusual blood coagulation factor, circulating as a heterotetramer composed of two catalytic A-subunits and two noncatalytic…
Fibrinogen Structure and Function
Fibrinogen Structure and Function John W. Weisel Carl-Erik H. Dempfle Fibrinogen, originally factor I (FI) in the clotting cascade, is a fibrous adhesive glycoprotein, present in the plasma at a…
The Factor XII-Driven Plasma Contact System
The Factor XII-Driven Plasma Contact System Thomas RennÉ SUMMARY The contact system is a protease cascade that is initiated by coagulation factor XII activation and operates on cardiovascular cells. The…
Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins
Structure and Function of Vitamin K-Dependent Coagulant and Anticoagulant Proteins Kanagasabai Vadivel Amy E. Schmidt Victor J. Marder Sriram Krishnaswamy S. Paul Bajaj Physiologic coagulation is initiated when, upon vascular…
Structure and Function of von Willebrand Factor
Structure and Function of von Willebrand Factor Sandra L. Haberichter Robert R. Montgomery von Willebrand disease (vWD) is the most common hereditary bleeding disorder with a prevalence estimated by some…
