Hodgkin’s Disease
Hodgkin’s Disease Dan L. Longo Hodgkin’s disease is a clonal lymphoid malignancy mainly confined to lymph nodes and lymphoid organs. For the period 1960–1963, 5-year survival from Hodgkin’s disease was…
Renal Cell Carcinoma
Renal Cell Carcinoma M. Dror Michaelson INTRODUCTION The incidence of renal cell carcinoma (RCC) in the United States has been rising steadily, with an estimated 65,150 cases and 13,680 deaths…
Primary Squamous Carcinoma of the Uterine Cervix: Diagnosis and Management
Primary Squamous Carcinoma of the Uterine Cervix: Diagnosis and Management Olivia Foley, Marcela G. del Carmen INTRODUCTION Squamous cell carcinoma of the uterine cervix comprises an estimated 80% of all…
Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lympho Jennifer Gao, Ephraim Paul Hochberg Lymphomas are a malignancy arising from lymphoid cells, with more than 60 distinct variants identified by the World Health Organization (WHO)….
Depression, Anxiety, and Fatigue
Depression, Anxiety, and Fatigue Carlos G. Fernandez-Robles, William F. Pirl INTRODUCTION Depression, anxiety, and fatigue are frequent complications of cancer and cancer treatment. Although fatigue can be caused by depression…
Immunomodulatory Drugs and Proteasome Inhibitors
Immunomodulatory Drugs and Proteasome Inhibitors Anuj Mahindra, Hamza Mujagic, Bruce A. Chabner The therapeutic options for the treatment of multiple myeloma (MM) have expanded over the past decade with the…
Adduct-Forming Agents: Alkylating Agents and Platinum Analogs
Adduct-Forming Agents: Alkylating Agents and Platinum Analogs Bruce A. Chabner Since the first clinical experiments with nitrogen mustard at Yale in the early 1940s, alkylating agents have played a primary…
Febrile Neutropenia
Febrile Neutropenia Stephen M. Carpenter, Fabrizio Vianello, Mark C. Poznansky INTRODUCTION Immune-compromised state refers to a change of the host defense systems that confer an increased susceptibility to infection. Neutropenia…
Acute Lymphoblastic Leukemia and Lymphoma
Acute Lymphoblastic Leukemia and Lymphoma James W. Fraser, Janet E. Murphy, Eyal C. Attar INTRODUCTION Acute lymphoblastic leukemia (ALL) is a highly aggressive neoplasm of hematopoietic cells of lymphoid lineage….
