FIGURE 30-1. Extreme cachexia in an anorexia nervosa patient. (From Bliss EL, Branch CHH: Anorexia Nervosa: Its History, Psychology, and Biology. New York: Paul B. Hoeber, 1960.) A corollary of…
FIGURE 2-1. Chemical structure of DNA and its relationship to chromatin. The most basic unit of the chromosome is DNA, which is composed of polynucleotide chains made up of four…
FIGURE 29-1. A, Clinical response to leptin therapy in congenital leptin deficiency. B, Leptin therapy is associated with pulsatile gonadotropin secretion at an appropriate developmental age in child A (age…
Possible mechanisms by which pancreatic cancer could contribute to the development of type 2 diabetes include the following: (1) destruction of islets, (2) impairment of the insulin secretory mechanism, (3)…
FIGURE 38-1. Congenital lipodystrophy. Although there is a lack of consensus on the definition of the lipodystrophy syndrome(s), the diagnosis of lipodystrophy is usually made clinically and is often based…
Pituitary Development ORIGIN Phylogenetic studies in several vertebrate species led to the conclusion that the pituitary gland arises from oral epithelia. Fate-mapping experiments conducted in these animal species trace the…
PERIOPERATIVE MANAGEMENT Use of glucocorticoids to reduce peritumoral edema, cerebrospinal fluid diversion to treat hydrocephalus, anticonvulsants to prevent seizures, and hormonal replacement for patients with tumors in the hypothalamic-pituitary region…
FIGURE 6-1. Modular structure of nuclear hormone receptors. The most highly conserved domain is the DNA-binding domain, DBD, followed by the ligand-binding domain, LBD. The domains are sometimes also referred…
