Thrombotic Microangiopathies in Pregnancy

Oct 31, 2016 by in HEMATOLOGY Comments Off on Thrombotic Microangiopathies in Pregnancy

  Primary features Pathophysiology Complications Treatment DIC Abnormal coagulation (increased PT, APTT, reduced fibrinogen and platelets) Underlying precipitant, e.g. placental abruption, sepsis Excessive bleeding or thrombosis Treat the underlying cause…

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Thrombocytopenia in Pregnancy: Gestational Thrombocytopenia and Immune Thrombocytopenic Purpura

Oct 31, 2016 by in HEMATOLOGY Comments Off on Thrombocytopenia in Pregnancy: Gestational Thrombocytopenia and Immune Thrombocytopenic Purpura

Variable GT ITP Gestational age at diagnosis (weeks) 32.8 ± 7.6 20.1 ± 11.1 Gestational age when platelet count counts at nadir (weeks) 35.7 ± 5.5 27.0 ± 11.2 Platelet count at diagnosis (×109/L) 71.3 ± 19.2 40.0 ± 25.5 Platelet count…

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Inherited Bleeding Disorders in Pregnancy: Platelet Defects

Oct 31, 2016 by in HEMATOLOGY Comments Off on Inherited Bleeding Disorders in Pregnancy: Platelet Defects

Severe phenotype platelet function disorders Severe Glanzmann thrombasthenia Severe Bernard-Soulier syndrome Non-severe phenotype disorders Defects in platelet aggregation or adhesion Rare Glanzmann thrombasthenia variants (type II) Rare Bernard-Soulier syndrome variants…

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Pre-eclampsia: The Role of Hemostasis in Its Pathophysiology and Potential Future Therapeutic Options

Oct 31, 2016 by in HEMATOLOGY Comments Off on Pre-eclampsia: The Role of Hemostasis in Its Pathophysiology and Potential Future Therapeutic Options

History Previous pre-eclampsia Chronic hypertension Renal disease Type 1 or type 2 diabetes Multiple pregnancy Family history of pre-eclampsia Antiphospholipid syndrome Chronic autoimmune disease Increasing maternal age beyond 34 years…

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Anticoagulants and Antiplatelet Agents in Pregnancy

Oct 31, 2016 by in HEMATOLOGY Comments Off on Anticoagulants and Antiplatelet Agents in Pregnancy

Fig. 2.1 Coagulation mechanism and targets for action of different anticoagulants. UFH unfractionated heparin, AT antithrombin, LMWH low-molecular-weight heparin The amount of activated factor X is further enhanced by the…

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