Primary features Pathophysiology Complications Treatment DIC Abnormal coagulation (increased PT, APTT, reduced fibrinogen and platelets) Underlying precipitant, e.g. placental abruption, sepsis Excessive bleeding or thrombosis Treat the underlying cause…
Author and year HPA-1a (%) HPA-1b (%) HPA-3a (%) HPA-5a (%) HPA-5b (%) HPA-15 (%) HPA-1a & HPA-5b (%) Other (%) Reznikoff-Etievant (1988) [23] 90 Mueller-Eckhardt et al. (1989) [24]…
Variable GT ITP Gestational age at diagnosis (weeks) 32.8 ± 7.6 20.1 ± 11.1 Gestational age when platelet count counts at nadir (weeks) 35.7 ± 5.5 27.0 ± 11.2 Platelet count at diagnosis (×109/L) 71.3 ± 19.2 40.0 ± 25.5 Platelet count…
Severe phenotype platelet function disorders Severe Glanzmann thrombasthenia Severe Bernard-Soulier syndrome Non-severe phenotype disorders Defects in platelet aggregation or adhesion Rare Glanzmann thrombasthenia variants (type II) Rare Bernard-Soulier syndrome variants…
Fig. 12.1 Prevalence of RBDs according to WFH 2011 survey (www.wfh.org) (closed bars) and EN-RBD (www.rbdd.eu) (open bars) 12.2 Classification of RBDs Most RBDs are expressed phenotypically as a parallel…
Maternal age over 40 years Multiparity Previous Cesarean section Uterine scarring (previous myomectomy, uterine curettage) Previous spontaneous or induced miscarriage Cigarette smoking and use of drugs such as cocaine Multiple…
History Previous pre-eclampsia Chronic hypertension Renal disease Type 1 or type 2 diabetes Multiple pregnancy Family history of pre-eclampsia Antiphospholipid syndrome Chronic autoimmune disease Increasing maternal age beyond 34 years…
Clinical criteria (one or more) Vascular thrombosis: One or more objectively confirmed episodes of arterial, venous or small vessel thrombosis occurring in any tissue or organ Pregnancy morbidity: One or…
Fig. 7.1 Implantation spectrum Pregnancy itself is a prothrombotic state – characterized by an increase in the levels of pro-coagulant factors, a simultaneous decrease in the levels of anticoagulant proteins,…
© Springer-Verlag London 2015Hannah Cohen and Patrick O’Brien (eds.)Disorders of Thrombosis and Hemostasis in Pregnancy10.1007/978-3-319-15120-5_1 1. Hemostatic Changes in Normal Pregnancy Carolyn M. Millar1 and Michael Laffan1 (1) Centre for Haematology, Faculty of Medicine, Hammersmith Campus, Imperial College,…
