Male Breast Cancer
Male Breast Cancer Sarika Jain William J. Gradishar EPIDEMIOLOGY Male breast cancer (MBC) is a rare disease worldwide. As a result of its rarity, it is treated similarly to female…
Preoperative Systemic Therapy for Breast Cancer
Preoperative Systemic Therapy for Breast Cancer Marc E. Lippman Preoperative (or neoadjuvant) systemic therapy for breast cancer is a rapidly changing field with complex issues surrounding appropriate patient selection, management,…
Inflammatory Breast Cancer
Inflammatory Breast Cancer Beth Overmoyer Lori J. Pierce DEFINITION AND DIAGNOSTIC CRITERIA Historical Perspective The term “inflammatory breast cancer” (IBC) was first introduced by Lee and Tannenbaum in their sentinel…
Locally Advanced Breast Cancer
Locally Advanced Breast Cancer Gabriel N. Hortobagyi Funda Meric-Bernstam Eric A. Strom DEFINITION Locally advanced breast cancer (LABC) remains an important public health problem and a challenging management problem around…
Local-Regional Therapy following Systemic Treatment
Local-Regional Therapy following Systemic Treatment Thomas A. Buchholz Kelly K. Hunt INTRODUCTION The sequencing of systemic treatments prior to performing definitive breast cancer surgery has become increasingly common. This approach,…
Pathologic Assessment of Treatment Response after Neoadjuvant Therapy
Pathologic Assessment of Treatment Response after Neoadjuvant Therapy Sunati Sahoo Susan Carole Lester INTRODUCTION Neoadjuvant therapy (NAT) reveals the response of cancers to therapy in vivo and, thus, generates a…
Preoperative Endocrine Therapy for Operable Breast Cancer
Preoperative Endocrine Therapy for Operable Breast Cancer Ian E. Smith INTRODUCTION Preoperative estrogen therapy was first described more than 50 years ago for postmenopausal women with large and sometimes locally…
Preoperative Chemotherapy for Operable Breast Cancer
Preoperative Chemotherapy for Operable Breast Cancer Aditya Bardia José Baselga INTRODUCTION Preoperative chemotherapy, also referred to as neoadjuvant chemotherapy or primary systemic therapy, today constitutes one of the standards of…
Adjuvant Systemic Therapy Treatment Guidelines
Adjuvant Systemic Therapy Treatment Guidelines C. Kent Osborne Adjuvant therapy decisions have become more complicated as breast cancers are further subdivided into groups that mandate different treatment approaches. Division of…
Long-Term and Late Effects of Primary Curative Intent Therapy: Neurocognitive, Cardiac, and Secondary Malignancies
Long-Term and Late Effects of Primary Curative Intent Therapy: Neurocognitive, Cardiac, and Secondary Malignancies Rena D. Callahan Patricia A. Ganz The number of women living in the United States with…
