Bartonellosis
Chapter 42 Bartonellosis Jane E. Koehler, MD BARTONELLA INFECTIONS Clinical Presentation The spectrum of disease caused by Bartonella species includes cat scratch disease (B. henselae), bacillary angiomatosis (B. henselae and…
Integrase Inhibitors and Other New Drugs in Development
Chapter 27 Integrase Inhibitors and Other New Drugs in Development John J.W. Fangman, MD, Martin S. Hirsch, MD INTRODUCTION Since the second edition of AIDS Therapy in 2003, substantial advances…
Emtricitabine
Chapter 10 Emtricitabine Michael J. Mugavero, MD, MHS, Melissa F. Wellons, MD, MHS Emtricitabine is a pyrimidine analog with antiviral activity against human immunodeficiency virus (HIV) and hepatitis-B virus (HBV)…
Primary Care in Developed Countries
Chapter 2 Primary Care in Developed Countries David H. Spach, MD, Kenneth H. Mayer, MD In developed countries, persons infected with human immunodeficiency virus (HIV) have experienced a profound improvement…
Zalcitabine
Chapter 7 Zalcitabine John A. Bartlett, MD Zalcitabine (2′,3′-dideoxycytidine, ddC, HIVID) is a pyrimidine analog whose synthesis was originally described by Horwitz et al in 1966.1 The antiretroviral activity of…
Therapeutic Vaccines
Chapter 31 Therapeutic Vaccines Anna R. Thorner, MD, Dan H. Barouch, MD, PhD INTRODUCTION Antiretroviral therapy (ART) has proven remarkably effective at reducing acquired immunodeficiency syndrome (AIDS)-related morbidity and mortality….
Complementary and Alternative Therapies
Chapter 32 Complementary and Alternative Therapies Jason Tokumoto, MD, Donald I. Abrams, MD BACKGROUND Complementary and alternative medicine (CAM) can be defined as “those healthcare and medical practices that are…
Zidovudine
Chapter 5 Zidovudine Jeffrey L. Lennox, MD, Margaret A. Fischl, MD Zidovudine (39-azido-39-deoxythymidine, AZT) (ZDV) is a pyrimidine nucleoside analog of thymidine (Fig. 5-1). ZDV differs from thymidine in that…
Delavirdine
Chapter 12 Delavirdine Lisa M. Demeter, MD, Richard C. Reichman, MD STRUCTURE Delavirdine (Rescriptor, previously U-90152) (Fig. 12-1) belongs to the bisheteroarylpiperazine (BHAP) class of non-nucleoside reverse transcriptase inhibitors (NNRTIs).1–3…
