Nelfinavir
Chapter 18 Nelfinavir Miguel A. Goicoechea, MD, Richard H. Haubrich, MD Nelfinavir (Viracept) was the fourth protease inhibitor (PI) approved by the US Food and Drug Administration (FDA) for the…
Lamivudine
Chapter 9 Lamivudine James H. Willig, MD, Joseph J. Eron, Jr, MD STRUCTURE Lamivudine (3TC, Epivir) is the negative or cis enantiomer of 2′-deoxy-3′-thiacytidine that has antiviral activity against human…
Cryptosporidia, Isospora, and Cyclospora Infections
Chapter 38 Cryptosporidia, Isospora, and Cyclospora Infections Timothy P. Flanigan, MD, Christine A. Wanke, MD It has only been since the recognition of the acquired immunodeficiency syndrome (AIDS) epidemic that…
Establishing the Diagnosis of HIV Infection
Chapter 1 Establishing the Diagnosis of HIV Infection Bernard M. Branson, MD, J. Steven McDougal, MD Treatment, especially highly active antiretroviral therapy (HAART), has dramatically improved survival for persons infected…
Occupational and Nonoccupational Exposure Management
Chapter 34 Occupational and Nonoccupational Exposure Management* Adelisa L. Panlilio, MD, MPH, Lisa A. Grohskopf, MD, MPH INTRODUCTION The primary means of preventing HIV transmission is by avoiding exposure to…
Human Herpesvirus-6 and Herpesvirus-7 Infections
Chapter 52 Human Herpesvirus-6 and Herpesvirus-7 Infections David W. Kimberlin, MD, John W. Gnann, Jr, MD In 1986 a novel virus was isolated from six patients with lymphoproliferative syndromes, two…
Pharmacogenetics of Antiretroviral Agents
Chapter 29 Pharmacogenetics of Antiretroviral Agents Catia Marzolini, PharmD, PhD, Richard Kim, MD, Amalio Telenti, MD, PhD INTRODUCTION Pharmacogenomics is an emerging clinical discipline that explores the interaction of drugs…
Nevirapine
Chapter 13 Nevirapine Marianne Harris, MD, CCFP, Carlos Zala, MD, Robert Hogg, PhD, Julio S.G. Montaner, MD Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. It inhibits…
HIV Resistance Testing in Clinical Practice
Chapter 28 HIV Resistance Testing in Clinical Practice Charles A.B. Boucher, MD, PhD, Andrew R. Zolopa, MD, Richard T. D’Aquila, MD INTRODUCTION During the last decade our understanding of both…
