Adoptive Cellular Immunotherapy Stephen Gottschalk Cliona M. Rooney Malcolm K. Brenner INTRODUCTION Over the last thirty years, a multidisciplinary approach including chemotherapy, radiation, surgery, and/or hematopoietic stem cell transplantation (HSCT)…
General Principles of Radiation Oncology Ralph P. Ermoian Shannon E. Fogh Steve Braunstein Kavita K. Mishra Larry E. Kun Daphne A. Haas-Kogan Radiation oncology is a clinical discipline focused on…
Molecularly Targeted Therapies and Biotherapeutics Malcolm A. Smith INTRODUCTION With the approval of the BCR-ABL inhibitor imatinib for the treatment of chronic myeloid leukemia (CML) by the Food and Drug…
General Principles of Chemotherapy Peter C. Adamson Susan M. Blaney Rochelle Bagatell Jeffrey M. Skolnik Frank M. Balis Since the introduction of chemotherapy for the treatment of childhood leukemia more…
Imaging Studies in the Diagnosis and Management of Pediatric Malignancies Rajesh Krishnamurthy Heike E. Daldrup-Link Jeremy Y. Jones Stephan D. Voss Geetika Khanna Farahnaz Golriz Robert P. Guillerman INTRODUCTION Since…
Diagnostic Pathology of Pediatric Malignancies Timothy J. Triche John M. Hicks Poul H. Sorensen OVERVIEW Cancer in children and adolescents is distinct from that seen in adults and requires a…
Pathology and Molecular Diagnosis of Leukemias and Lymphomas Amy Heerema-McKenney Michael L. Cleary Daniel A. Arber INTRODUCTION This chapter focuses on the pathologic diagnosis of pediatric hematopoietic neoplasms and their…
Clinical Assessment and Differential Diagnosis of the Child with Suspected Cancer Wendy Allen-Rhoades Charles P. Steuber INTRODUCTION Cancer, a common disease in adults, is rare in children and adolescents (see…
Tumor Immunology and Pediatric Cancer Terry J. Fry Paul M. Sondel Crystal L. Mackall The immune system is a complex network of cells and soluble factors that has evolved to…
Biology of Childhood Cancer Christopher Denny Daniel S. Wechsler Kathleen M. Sakamoto INTRODUCTION The age-old axiom that pediatric patients are not simply small adults with disease definitely holds true in…
