The Nonrhabdomyosarcoma Soft Tissue Sarcomas Sheri L. Spunt Lynn Million Cheryl Coffin INTRODUCTION Although soft tissue sarcomas (STSs) account for fewer than 1% of all cancers in the general population,…
Rhabdomyosarcoma Leonard H. Wexler Stephen X. Skapek Lee J. Helman A malignant tumor of mesenchymal cell origin is called a sarcoma. Mesenchymal cells normally mature into skeletal muscle, smooth muscle,…
Neuroblastoma Garrett M. Brodeur Michael D. Hogarty Rochelle Bagatell Yael P. Mossé John M. Maris INTRODUCTION Few tumors have engendered as much fascination and frustration for clinicians and researchers as…
Renal Tumors Conrad V. Fernandez James I. Geller Peter F. Ehrlich Ashley D. Hill John A. Kalapurakal Jeffrey S. Dome INTRODUCTION The kidney is the site of approximately 7% of…
Liver Tumors Rebecka L. Meyers Angela D. Trobaugh-Lotrario Marcio H. Malogolowkin Howard M. Katzenstein Dolores H. López-Terrada Milton J. Finegold HISTORICAL CONTEXT Benign and malignant liver tumors in children are…
Retinoblastoma Richard L. Hurwitz Carol L. Shields Jerry A. Shields Patricia Chévez-Barrios Dan S. Gombos Mary Y. Hurwitz Murali M. Chintagumpala INTRODUCTION Retinoblastoma, a malignant tumor of the embryonic neural…
Embryonal and Pineal Region Tumors Murali M. Chintagumpala Arnold Paulino Ashok Panigrahy Cynthia Hawkins Andrew Jae Williams D. Parsons EMBRYONAL TUMORS Embryonal tumors constitute approximately 25% of all primary central…
Gliomas, Ependymomas, and Other Nonembryonal Tumors of the Central Nervous System Williams D. Parsons Ian F. Pollack Daphne A. Hass-Kogan Tina Y. Poussaint Adekunle M. Adesina Murali M. Chintagumpala Tumors…
Histiocytic Diseases Kenneth L. McClain Carl E. Allen John M. Hicks INTRODUCTION Histiocytic disorders are a group of diseases that are characterized by abnormal differentiation or function of “histiocytes.” Although…
Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies Robert J. Hayashi Birte Wistinghausen Bruce Shiramizu INTRODUCTION In 1959, Thomas conceptualized that the immune system played a role in oncogenesis. He hypothesized…
