Activity type Considerations Reagent preparation 1. Perform in cleanest environment 2. Store working stock solutions in single-use aliquots 3. Quality control each new set of reagents before use in clinical…
Fig. 1.1 Structure of elements comprising the eukaryote protein coding (mRNA) gene. Modified from [40]. Used under creative commons attribution license DNA Encoding Messenger RNA, Enhancers, and snRNA The eukaryotic…
Tumor type Prevalence (%) Papillary carcinoma BRAF 40–45 RET/PTC 10–20 RAS 10–20 TRK <5 Follicular carcinoma RAS 40–50 PAX8-PPARγ (PAX8-PPARG) 30–35 PIK3CA <10 PTEN <10 Poorly differentiated carcinoma RAS 20–40…
Fig. 4.1 (40× and 200×) Specimens with predominantly tumor and minimal non tumor diluting cells. This is still not 100 % tumor as there are still non tumor nucleated cells…
Fig. 9.1 Illustration of image-guided radiotherapy. Red contours indicate the prostates Many methods have been proposed to address this paramount yet compelling segmentation problem. For example, Freedman et al. [10]…
(3.1) where UΣV T is the singular value decomposition of X. This is equivalent to transformation into a new coordinate system such that the greatest variance by any projection of…
Fig. 6.1 Visual representation of the sample ontology Table 6.1 RDF representation of a patient based on the ontology of Fig. 6.1 Subject Predicate Object mySet:patient1001 rdf:type ncit:C16960 mySet:patient1001 myOntology:hasFirstName…
Fig. 11.1 An example of regular breathing Fig. 11.2 An example of highly irregular breathing Fig. 11.3 A sequence of measurements of tumor position and chest marker position, showing a…
(8.1) where f(u, v) is a function determined using a machine learning approach, which we choose to be support vector machine (SVM) learning [26], and ζ is the modeling error. The…
Fig. 7.1 Flowchart for a generic CADe scheme for the detection of lesions in diagnostic images. Boxes with solid lines indicate four core steps in the CADe scheme, and those…
