Fig. 1 Numbers of somatic structural variants (SV) and single nucleotide variants (SNVs) identified in prostate (Berger et al. 2011) and colorectal cancer (Bass et al. 2011) Insight into structural genomic…

Fig. 1 Telomere-DNA is an evolutionarily conserved GT-rich repetitive sequence. Basically all eukaryotes use GT-rich repetitive sequences at the ends of their chromosomes (telomeres). Despite considerable variation in telomere length and…

Fig. 1 Karyotype aberrations. Doubling the karyotype results in polyploidy, whereas loss or gain of one entire chromosome results in whole chromosome aneuploidy. Unbalanced structural rearrangements such as gain or loss…

Fig. 1 Schematic illustration of commonly observed numerical and structural chromosome alterations identified in solid tumors, and the methodologies capable of their detection. Detection of an alteration, however, is not necessarily…

Fig. 1 Summary of the major mechanisms causing CIN in human cancer cells. The major defects leading to chromosome missegregation in human cancer cells are a premature loss of sister chromatid…

Fig. 1 a HDAC2 and TXNL1 immunohistochemical detection in colorectal cancer specimens based on a tissue microarray. Image examples are given at 800-fold magnification. b Tissue-microarray-based immunohistochemical evaluation of HDAC2 and…

Fig. 1 Schematic overview of various genes targeted to provoke CIN in vivo 3 In Vivo Consequences of CIN In the last two decades, a large number of mouse models for…