Ovarian Cancer Screening and Early Detection
Biomarker Description Method Reference CA 15-3 Tumor antigen Serum ELISA Woolas et al. [41] CA 19-9 Tumor antigen Serum ELISA Woolas et al. [41] TAG-72 Tumor antigen Serum ELISA Woolas…
ONCOLOGY
Management of Patients with Early-Stage Ovarian Cancer
Professional group Recommendation US Preventive Services Task Force Does not recommend routine screening, concluding that “the potential harms outweigh the potential benefits” American Cancer Society Does not recommend routine screening;…
Psychological Aspects of Hereditary and Non-hereditary Ovarian Cancer
Level of evidence Factor Most frequently observed observation Strong Age Younger age—more distress Disease stage More advanced disease—more distress Time since diagnosis Shorter—more distress Disability status Worse—more distress Physical symptoms…
Genetic Risks of Ovarian Cancer
Syndrome Manifestations Inheritance Gene(s) Reference Hereditary breast and ovarian cancer Early-onset breast or ovarian cancer, multiple primary cancers, cancer in several generations, male breast cancer AD BRCA1 [19] BRCA2 [20]…
Management of Hereditary Ovarian–Breast Cancer
Established risk factors Possible risk factors Suspected risk factors Age Early age at menarche Hormonal replacement therapy Family history – genetics Late age at menopause Dietary fat Nulliparity Infertility Obesity…
Epidemiology of Ovarian Cancer: An Update
Fig. 1.1 Worldwide ovarian cancer incidence and mortality rates. Rates are per 100,000 and represent age-standardized rates according to the world standard population (ASR (W)) (From the International Agency for…
Strategies for the Management of Ovarian Cancer
9. Eisenhauer EL, Abu-Rustum NR, Sonoda Y, Levine DA, Poynor EA, Aghajanian C, et al. The addition of extensive upper abdominal surgery to achieve optimal cytoreduction improves survival in patients…
Apoptosis Induction and Regulation
(1) Institut Bergonié, Bordeaux, France Abstract Apoptosis is one of the main modalities of cell death, so important that it has outshined all others that only begin to be…
Cell Cycle Control
(1) Institut Bergonié, Bordeaux, France Abstract Cell cycle consists of the sequential events occurring between the emergence of a new cell and that of the two daughter cells generated…
Signalling by Oxygen and Nitric Oxide
(1) Institut Bergonié, Bordeaux, France Abstract Oxygen is, first of all, the combustive agent required for life and the provider of energy required by all heterotrophic organisms, those which…
