Testicular Cancer Timothy Gilligan EPIDEMIOLOGY Although testis cancer is rare when viewed across the lifespan, it is the most common malignancy in men aged 20-35 years. Thanks to the high…

Localized Prostate Cancers Jason A. Efstathiou, Phillip J. Gray, Douglas M. Dahl EPIDEMIOLOGY In the United States, an estimated 238,590 men will be diagnosed with prostate cancer in 2013 with…

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The Taxanes, Vinca Alkaloids, and Their Derivatives Bruce A. Chabner INTRODUCTION In the past decade, the taxanes have emerged as one of the most powerful classes of anticancer drugs (1)….

Acute Myeloid Leukemia Amir T. Fathi ETIOLOGY AND EPIDEMIOLOGY Acute myeloid leukemia (AML) is an aggressive and frequently lethal hematologic malignancy, with a median age of presentation beyond the sixth…

Primary Brain Tumors Andrew S. Chi INTRODUCTION Over 100 types of primary brain tumor are defined by the World Health Organization (WHO), the most commonly accepted classification system (1). Only…

Cholangiocarcinoma and Gallbladder Cancers Janet E. Murphy, Andrew X. Zhu INTRODUCTION Biliary tract cancers (BTCs) are invasive carcinomas that arise from the epithelial lining of the gallbladder and bile ducts….

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Hodgkin’s Disease Dan L. Longo Hodgkin’s disease is a clonal lymphoid malignancy mainly confined to lymph nodes and lymphoid organs. For the period 1960–1963, 5-year survival from Hodgkin’s disease was…

Renal Cell Carcinoma M. Dror Michaelson INTRODUCTION The incidence of renal cell carcinoma (RCC) in the United States has been rising steadily, with an estimated 65,150 cases and 13,680 deaths…