Fig. 14.1 Acetaldehyde production by Streptococcus gordonii on the PBB-Schiff’s agar. (1) V2016wt; (2) ΔadhA; (3) ΔadhB; (4) ΔadhAB; (5) ΔadhE; (6) ΔadhAE; (7) ΔadhBE; (8) ΔadhABE 14.2.4 Alcohol Dehydrogenases…
Fig. 13.1 Step-wise workflow for urinary metabolomic analysis to identify biomarkers of alcohol-induced liver disease (ALD). Wild-type and Ppara-null B6 and 129S mice were placed in the 4 % EtOH…
Fig. 24.1 Alcohol exposure in utero increases total number of mammary tumors in offspring. (a) Rats exposed in utero to low (7 % of total calories) or moderate (15 %…
Fig. 18.1 Chronic alcohol consumption-induced inhibition on B16BL6 melanoma metastasis is IFN-γ-dependent. (a) Images showing colonies of melanoma (black dots) on the lung of water-drinking mice and alcohol-consuming mice. (b,…
Fig. 6.1 Iron accumulation and ROS are important factors in the alcohol-mediated hepatocarcinogenesis 6.2 Health Statistics of ALD Chronic alcohol consumption is one of the major risk factors worldwide, significantly…
Fig. 7.1 Five-year cumulative incidence of HCC in different etiologies of liver cirrhosis (Data from Fattovich et al., Gastroenterology 2004;127:S35-50) Obviously, structural and functional abnormalities pertinent to alcoholic cirrhotic transformation…
Fig. 12.1 Alcohol and HCV in liver disease: common sites of action 12.2 Alcohol, HCV and Innate Immunity The immune response is a common target of both alcohol and the…
Fig. 21.1 Tumor incidence in two models of HCC and EtOH consumption. (a) Twenty-one-day-old male C57BL/6 or B6C3 mice were injected with vehicle (Veh; 100 μL sterile olive oil) or…
Fig. 17.1 CEA processing and metastatic potential of colorectal cancer cells (CRC) in the alcohol-injured liver. (a) The potential effects of alcohol on the direct processing of CEA by Kupffer…
Fig. 5.1 The reaction of acetaldehyde with deoxyguanosine results in the formation of N2-ethylidendene-dG; this unstable Schiff base can be converted through a reduction step to the more stable form:…
