Study Patients Chemotherapy type Time of assessment Age Cognitive assessment Results Mayerhofer et al. [27] Patients with advanced ovarian cancer (n = 28) Paclitaxel/carboplatin Before CT, after cycle 3, and after CT…
AGO-OVAR [11] GOG [37] EORTC 55971 pCRS iCRS [36] CHORUS pCRS iCRS [15] Suboptimal > 1 cm 29.6 months 35.0 months 26 months 25 22.8–24.5 Gross optimal ≤ 1 cm 36.2 months 42.4 months 32…
© Springer International Publishing Switzerland 2016Gilles Freyer (ed.)Ovarian Cancer in Elderly Patients10.1007/978-3-319-23588-2_9 9. Biological Research: Current Directions Claire Falandry1 , M. Bonnefoy1, Gilles Freyer2 and E. Gilson3, 4 (1) Geriatrics Unit, CarMEN Laboratory, Lyon Sud University Hospital, Lyon University,…
Albuminemia <35 g/L Lymphopenia <1 G/L ADL score <6 IADL score <25 HADS score >14 The number of points is the sum of “yes” A vulnerable patient is defined as…
© Springer International Publishing Switzerland 2016Gilles Freyer (ed.)Ovarian Cancer in Elderly Patients10.1007/978-3-319-23588-2_8 8. How to Design Clinical Trials? Sandro Pignata1 , Sabrina Chiara Cecere1 and Rosa Tambaro1 (1) Dipartimento Uro-Ginecologico, Istituto Nazionale Tumori “Fondazione G Pascale” – IRCCS, Naples,…
HG serous LG serous Mucinous Endometrioid Clear cell Incidence 70 % <5 % 3 % 10 % 5–10 % Risk factors BRCA1/2 ? ? HNPCC HNPCC+/- Precursor lesions STIC…
Clinical trial Phase Treatment schema N Median age [range] Responses CR + PR or HR Median PFS Cannistra (2007) [6] II Bev monotherapy 44 59.5 [31–87] 16 % 4.4 months Burger (2007)…
C-PLD C-P p Febrile neutropenia None 100 94 0.038 Present 0 6 Alopecia None 89 14 <0.001 Partial/complete 11 86 Sensory neuropathy Grade 0–1 90 64 <0.001 Grade 2–3…
GC-MS Sensor array Compounds Volatile and semi-volatile compounds Tunable through choice of sensors Accuracy of compound identification Very high No compound identification Detection limit ~ppm v , can be…
Organization Screening recommendations AAFP Every 1–2 years, ages 50–69; counsel women ages 40–49 about potential risks and benefits of mammography and clinical breast examination ACOG Every 1–2 years starting at…
