Tumor suppressor genes David Cosgrove, MB, BCh Ben Ho Park, MD, PhD Bert Vogelstein, MD Overview Cancer is a genetic disease. Mutations and other alterations in growth promoting genes (oncogenes)…

Molecular diagnostics in cancer Roshni D. Kalachand, MBBCh, MD Bryan T. Hennessy, MD Robert C. Bast Jr. MD Gordon B. Mills, MD, PhD Overview Molecular diagnostics refers to the use…

Differentiation therapy Sai-Juan Chen, MD, PhD Xiao-Jing Yan, MD Guang-Biao Zhou, MD Zhu Chen, PhD Overview Abnormal differentiation is one of the main features of human cancers, especially in hematological…

Drug resistance and its clinical circumvention Jeffrey A. Moscow, MD Kenneth H. Cowan, MD, PhD Branimir I. Sikic, MD Overview Tumors initially sensitive to chemotherapeutic agents frequently develop resistance to…