Non-Hodgkin Lymphoma of Childhood
Syndrome Tumor Risk (%) Percent of malignancies that equal NHL Ataxia-telangiectasia Leukemia, NHL, HL, adenocarcinoma >12 41–66 Common variable ID NHL, gastric carcinoma 8–10 45–62 Severe combined ID NHL, HL,…
ONCOLOGY
Platelet and Granulocyte Transfusion
Method Total white blood cells Platelets × 1011 References Mechanical apheresis Cobe spectra V5-LRS <1 × 106 2.56–7.41 [15] Fenwal amicus <1 × 106 2.82–7.14 [15] Cobe V7 turbo <1…
Cytogenetics of Lymphomas
Fig. 44.1 Partial karyotypes of chromosome abnormalities observed in lymphoid malignancies. The abnormal chromosomes are situated on the right side of each pair with the normal homologue on the left….
History of Multiple Myeloma
Fig. 26.1 Plasma cells obtained at the autopsy of Thomas Alexander McBean, January 1846 (wood engravings made from drawings by Mr. Dalrymple) (Reprinted with permission from Dalrymple J. On the…
Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications
Acquired Malignant Nonmalignant Congenital Acute nonlymphoblastic Leukemia Acute lymphoblastic leukemia Chronic myelogenous leukemia Chronic lymphocytic leukemia Non-Hodgkin lymphoma Hodgkin disease Multiple myeloma Myelodysplastic Syndrome Myelofibrosis Agnogenic myeloid metaplasia P. vera…
Viral Infections in Patients with Hematological Malignancies
Herpesviruses Herpes simplex type 1 Herpes simplex type 2 Cytomegalovirus Varicella zoster virus Epstein–Barr virus Human herpesvirus 6 Intestinal viruses Rotavirus Norwalk virus Adenoviruses Astroviruses Coxsackie Caliciviruses Respiratory viruses Respiratory…
Cytogenetic Abnormalities in MGUS and Myeloma
Non-hyperdiploid MM Hyperdiploid MM Translocations Less translocations Younger Older IgA IgG Lambda Kappa Less bone disease More bone disease More aggressive More indolent Females Males Chromosome 13 deleted Chromosome 13…
Diagnosis and Treatment of Hodgkin’s Lymphoma
Classification Stage I Involvement of a single lymph node region or lymphoid structure (e.g., spleen, thymus, Waldeyer’s ring) or involvement of a single extralymphatic site (IE) Stage II Involvement of…
The Myelodysplastic Syndromes
Fig. 25.1 The incidence of MDS and age. Age adjusted incidence/100,000 individuals. Age in five block years. (Data from Rollison DE, Howlader N, Smith MT et al. Epidemiology of myelodysplastic…
Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia
B lymphoblastic leukemia B lymphoblastic leukemia, not otherwise specified B lymphoblastic leukemia with recurrent genetic abnormalities B lymphoblastic leukemia with t(9;22)(q34;q11.2); BCR-ABL1 B lymphoblastic leukemia with t(v;11q23); MLL rearranged B…
