Heavy-Chain Disease
Feature Type of heavy-chain disease α γ μ Year described 1968 1964 1969 Incidence Rare Very rare Very rare Age at diagnosis Young adult (<30 years) Older adult (60–70 years)…
ONCOLOGY
Pathology of Non-Hodgkin’s and Hodgkin’s Lymphomas
Low grade A. Malignant lymphoma, small lymphocytic Consistent with chronic lymphocytic leukemia Plasmacytoid B. Malignant lymphoma, follicular, predominantly small cleaved cell Diffuse areas Sclerosis C. Malignant lymphoma, follicular, mixed small…
Pathology of the Chronic Myeloid Leukemias
Fig. 3.1 Peripheral blood (PB) film from a patient with chronic myelogenous leukemia with an unusually high white cell count showing an increase of neutrophils, eosinophils, basophils, and granulocyte precursors….
Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis)
Fig. 37.1 An enlarged tongue in a patient with AL amyloidosis Fig. 37.2 Clinical presentation of classic vascular purpura The Congo Red Stain The only accepted diagnostic test to validate…
The Etiology of Acute Leukemia
Fig. 14.1 The two-hit model of acute leukemogenesis. This model hypothesizes that AML and ALL are the consequence of a combination of at least two broad classes of mutations. Class…
Psychological Aspects of Hematological Neoplasms
Cognitive Evaluation of the danger versus one’s coping resources. Focus is on the perceived threat while extraneous detail environmental details are blocked out (tunnel vision). For example, a patient may…
Immunobiology of Acute Leukemia
Earliest definition Current definition ECOG’s new definition Myeloid Myeloid Myeloid HLA-DR NEG HLA-DR NEG HLA-DRNEG CD34 HLA CD34 NEG CD11a NEG CD15 NEG CD18NEG CH15s POS CD133 NEG CD9 POS…
Diagnosis and Treatment of Multiple Myeloma
Disorder Disease definition References Monoclonal gammopathy of undetermined significance (MGUS) All 3 criteria must be met: •Serum monoclonal protein <3 g/dL •Clonal bone marrow plasma cells <10 %, and •Absence…
Epidemiology of Multiple Myeloma
Fig. 28.1 US myeloma mortality rates (age-adjusted, 2000 U.S. standard) by race and sex, 1953–1957 to 2003–2006 Rates specific for blacks, available since the early 1970s, are higher than rates…
Cytogenetics of Acute Leukemia
AML with t(8;21)(q22;q22)/RUNX1-RUNX1T1 (AML1-ETO) AML with inv(16)(p13.1q22) or t(16;16)(p13.1q22)/CBFB-MYH11 APL with t(15;17)(q22;q21)/PML-RARA AML with t(9;11)(p22;q23)/MLLT3 -MLL (specify other 11q23/MLL abnormality) AML with t(6;9)(p23;q34)/DEK-NUP214(CAN)a AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)/RPN1-MECOM a AML…
