Lymphoproliferative Disorders
Fig. 1 The histopathology of PTLD. a Infectious mononucleosis-like “early” PTLD lesion. b Monomorphic PTLD, Burkitt lymphoma type. c Polymorphic PTLD. d Positive EBV in situ hybridization stain in a PTLD…
ONCOLOGY
of the Marginal Zone Lymphomas
Site Procedure Gastric MALT lymphoma Stomach • Endoscopic ultrasound • H. pylori status (by IHC)a • FISH or molecular assay for the t(11;18) translocation Non-gastric MALT lymphoma Breast • Mammography…
and Therapy of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Clinical Stage Absolute lymphocyte count Lymphocyte doubling time Bone marrow infiltration pattern Treatment response Age Performance status Genetic IGHV mutational status FISH Low risk: del(13q) Intermediate risk: trisomy 12 High…
Hematopoietic Cell Transplantation in Non-Hodgkin’s Lymphomas
© Springer International Publishing Switzerland 2015Andrew M. Evens and Kristie A. Blum (eds.)Non-Hodgkin LymphomaCancer Treatment and Research16510.1007/978-3-319-13150-4_14 Allogeneic Hematopoietic Cell Transplantation in Non-Hodgkin’s Lymphomas Ibrahim Aldoss1 and Auayporn Nademanee1 (1) City of Hope National Medical Center,…
Management of Peripheral T-Cell Lymphomas
T-cell prolymphocytic leukemia T-cell large granular lymphocytic leukemia Chronic lymphoproliferative disorder of NK cell Aggressive NK leukemia Systemic EBV-positive T-cell lymphoproliferative disorder of childhood Hydroa vaccineforme-like lymphoma Adult T-cell leukemia/lymphoma…
of B-Cell Lymphomas: Diagnosis and Biomarker Discovery
Expected immunophenotype Follicular lymphoma CD19+, CD20+, IgM ± IgD, monotypic sIg+, CD10+, bcl-6+, bcl-2 ±, HGAL, LMO2; associated with CD21+/CD23+ follicular dendritic cell meshworks Lymphoplasmacytic lymphoma CD19+, CD20+, monotypic sIg+, IgM, CD22+,…
Strategies in Mantle Cell Lymphoma
Fig. 1 Our approach to MCL treatment Table 1 Frontline regimens in patients ≤70 years Frontline regimen Age (years) ORR (%) PFS/FFS OS R-Hyper-CVAD [16] ≤81 97 3 years 64 % (≤65 3 years 73 %)…
Immunoglobulins and Laboratory Recognition of Monoclonal Proteins
IgG IgA IgM IgD IgE Heavy chain Classes Gamma (γ) Alpha (α) Mu (μ) Delta (δ) Epsilon (ε) Subclasses IgG1, IgG2, IgG3, IgG4 IgA1, IgA2 None None None Light…
Histopathology, Morphology and Immunophenotyping of CLL
Fig. 7.1 Peripheral blood film showing typical CLL cells and a smear cell (1,000× magnification) Fig. 7.2 Peripheral blood film showing prolymphocytes along with typical CLL cells (1,000× magnification) In…
Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations
Fig. 16.1 ALL: PAS reaction. Note the block-like reaction product Fig. 16.2 AML (FABM0). Blasts with no differentiation. Peroxidase negative but with positive myeloid antigens by flow cytometry Fig. 16.3…
