Clinical Stage Absolute lymphocyte count Lymphocyte doubling time Bone marrow infiltration pattern Treatment response Age Performance status Genetic IGHV mutational status FISH Low risk: del(13q) Intermediate risk: trisomy 12 High…
© Springer International Publishing Switzerland 2015Andrew M. Evens and Kristie A. Blum (eds.)Non-Hodgkin LymphomaCancer Treatment and Research16510.1007/978-3-319-13150-4_14 Allogeneic Hematopoietic Cell Transplantation in Non-Hodgkin’s Lymphomas Ibrahim Aldoss1 and Auayporn Nademanee1 (1) City of Hope National Medical Center,…
T-cell prolymphocytic leukemia T-cell large granular lymphocytic leukemia Chronic lymphoproliferative disorder of NK cell Aggressive NK leukemia Systemic EBV-positive T-cell lymphoproliferative disorder of childhood Hydroa vaccineforme-like lymphoma Adult T-cell leukemia/lymphoma…
Fig. 1 Our approach to MCL treatment Table 1 Frontline regimens in patients ≤70 years Frontline regimen Age (years) ORR (%) PFS/FFS OS R-Hyper-CVAD [16] ≤81 97 3 years 64 % (≤65 3 years 73 %)…
Expected immunophenotype Follicular lymphoma CD19+, CD20+, IgM ± IgD, monotypic sIg+, CD10+, bcl-6+, bcl-2 ±, HGAL, LMO2; associated with CD21+/CD23+ follicular dendritic cell meshworks Lymphoplasmacytic lymphoma CD19+, CD20+, monotypic sIg+, IgM, CD22+,…
IgG IgA IgM IgD IgE Heavy chain Classes Gamma (γ) Alpha (α) Mu (μ) Delta (δ) Epsilon (ε) Subclasses IgG1, IgG2, IgG3, IgG4 IgA1, IgA2 None None None Light…
Fig. 7.1 Peripheral blood film showing typical CLL cells and a smear cell (1,000× magnification) Fig. 7.2 Peripheral blood film showing prolymphocytes along with typical CLL cells (1,000× magnification) In…
Fig. 16.1 ALL: PAS reaction. Note the block-like reaction product Fig. 16.2 AML (FABM0). Blasts with no differentiation. Peroxidase negative but with positive myeloid antigens by flow cytometry Fig. 16.3…
Feature Type of heavy-chain disease α γ μ Year described 1968 1964 1969 Incidence Rare Very rare Very rare Age at diagnosis Young adult (<30 years) Older adult (60–70 years)…
Low grade A. Malignant lymphoma, small lymphocytic Consistent with chronic lymphocytic leukemia Plasmacytoid B. Malignant lymphoma, follicular, predominantly small cleaved cell Diffuse areas Sclerosis C. Malignant lymphoma, follicular, mixed small…
