Indolent subtypes Frequency (%) Aggressive subtypes Frequency (%) Mycosis fungoides variants and subtypes 61 Sézary syndrome 4 Folliculotropic mycosis fungoides 6 Adult T-cell leukemia/lymphoma <1 Pagetoid reticulosis <1 Extranodal NK/T-cell…
T T1: Solitary skin involvement T1a: A solitary lesion <5 cm diameter T1b: A solitary >5 cm diameter T2: Regional skin involvement: multiple lesions limited to one body region or…
Fig. 7.1 (a) Extranodal NK/T-cell lymphoma of the nasal cavity. Small- to medium-sized tumor cells are intermingled with plasma cells. (b) EBER in situ hybridization revealed positive signal in the…
Fig. 12.1 Burkitt lymphoma. (a) In this example of a Burkitt lymphoma arising in the gastric wall of an HIV-positive patient, the tumor cells are slightly larger and more pleomorphic…
Fig. 10.1 Primary mediastinal B-cell lymphoma: (a) H&E staining, consists of the neoplastic large cells with clear cytoplasm, (b) fibrotic bands with compartmentalising alveolar fibrosis, (c) tumour cells express CD30…
Fig. 16.1 Fundoscopic examination of a patient with Waldenström’s macroglobulinemia demonstrating hyperviscosity-related changes including dilated retinal vessels, peripheral hemorrhages, and “venous sausaging” (Courtesy of Marvin Stone M.D.) 16.3.2 Immunophenotype The…
Fig. 14.1 Path slides to be chosen by pathologist Other cytogenetic abnormalities that have been reported in MALT lymphomas include t(11;18), t(14;18), t(1;14), t(3;14), and trisomy 8. The translocation t(11;18)…
Fig. 17.1 Blood smear of a B-cell prolymphocytic leukemia. An 84-year-old man presented with abdominal pain to the emergency room with a WBC of 140,000 and splenomegaly. There is marked…
Martin Dreyling and Michael E. Williams (eds.)Hematologic MalignanciesRare Lymphomas201410.1007/978-3-642-39590-1_4 © Springer-Verlag Berlin Heidelberg 2014 4. Signaling Pathways in Rare Lymphomas Andrew Lipsky1, Patricia Pérez-Galán3, Claudio Agostinelli4, Pier Paolo Piccaluga4, Stefano A. Pileri4 and Adrian Wiestner2 (1) Department of Internal Medicine, Montefiore Medical Center,…
Author (year) n PFS OS SMZL Thieblemont et al. (2002) 81 Presence of M-component Beta2 microglobulin ≥3 mg/L Presence of animmunological event Leukocytes ≥20 109/L Lymphocytosis ≥9 109/L Presence of…
