Gene Signature
Fig. 18.1 Therapy-targeted pathways in lung cancer Targeted therapy in lung cancer and the drugs that influence them. EGF, epidermal growth factor; TGF-α, transforming growth factor-α; EGFR, epidermal growth factor…
ONCOLOGY
Companion Diagnostics
Release date Title April 2005 Draft preliminary concept paper: Drug-Diagnostic Co-development Concept Paper July 2011 Draft Guidance for Industry and Food and Drug Administration Staff: In Vitro Companion Diagnostic Devices…
Management of Adverse Effects by Molecular Targeted Therapy and Immunotherapy
Adverse event Grade 1 Grade 2 Grade 3 Grade 4 Rash acneiform Papules and/or pustules covering<10 % BSA, which may or may not be associated with symptoms of pruritus or…
Lung Cancer Complicated with Interstitial Lung Diseases
Regimen N (%) AE (N) AE (%) Carboplatin + paclitaxel 140 35.4 12 8.6 Carboplatin + etoposide 82 20.7 3 3.7 Cisplatin + etoposide 38 9.6 4 10.5 Vinorelbine 30…
ALK Mutant
© Springer Science+Business Media Singapore 2017Yuichi Takiguchi (ed.)Molecular Targeted Therapy of Lung Cancer10.1007/978-981-10-2002-5_11 11. ALK Mutant Akihiko Gemma1 (1) Division of Pulmonary Medicine, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan…
Locally Advanced Non-small Cell Lung Cancer and Targeted Therapy
Author (study name) Year Radiation (Gy/fractions) Chemotherapy N of patients Overall survival Grade 3–4 pneumonitis (%) Treatment-related death (%) Induction Concurrent Consolidation Median (month) 2y rate (%) Hallqvist A (SATELLITE)…
Small Cell Lung Cancer and Molecular Targeted Therapy
Target Agent Study phase Result References VEGF-A Bevacizumab II Promising [20] II Promising [21] II Positive for PFS, but no benefit in OS [22] VEGFR-1, VEGFR-2, VEGFR-3 Cediranib II Negative…
Next-Generation Sequencing and Bioinformatics
Fig. 6.1 Typical primary analysis pipeline of WES (a) and WTS (b). Briefly, data processing is done as follows: data cleansing, mapping to reference genome, and variant call/read counting and…
The Problem
(1) Research Oncology, Guy’s Hospital, London, United Kingdom Abstract There is substantial evidence of deleterious health behaviour in males both in terms of high-risk activities and avoidance of contact…
