Mechanism Specification 1. Reduced antigen processing and presentation Downregulation or mutation of HLA class molecules 2. Tumour-permissive cytokine profile Increase of immunosuppressive cytokines: TGF-β, IL-6 Decrease of stimulatory cytokines: IL-2,…

Assessment of functioning Social assessment Definition: ability to live independently at home and in the community, physical performance (mobility, balance, fall risk) Definition: adequate social support to undergo treatment Measurement:…

  Setting Outcomes Janot et al. [19] GETTEC-GORTEC phase III trial (NCT00180934) n = 130 (65 each arm) Resectable recurrent HNC Sx + postoperative reRT (vs. Sx alone) Total 60…

© Springer International Publishing Switzerland 2017Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai and Brian O’Sullivan (eds.)Critical Issues in Head and Neck Oncology10.1007/978-3-319-42909-0_12 12. Salvage Surgery of Head and Neck Cancer C. René Leemans1   (1) VU University…

Fig. 11.1 Acute toxicity relative risk values (T RR) and relative max-grade values for 13 head and neck treatment groups ranked by increasing relative risk. P platinum, H hydroxyurea, 5-FU…

© Springer International Publishing Switzerland 2017Jan B. Vermorken, Volker Budach, C. René Leemans, Jean-Pascal Machiels, Piero Nicolai and Brian O’Sullivan (eds.)Critical Issues in Head and Neck Oncology10.1007/978-3-319-42909-0_10 10. Treatment of Viral-Associated HNC (OPC and NPC) Shao Hui Huang1, Melvin L. K. Chua2, Francesca Caparrotti2 and…

Fig. 4.1 Detection of high-risk HPV using RNAscope. Multiple nuclear dot-like signals are present in the neoplastic cells whilst the stromal cells are unlabeled Table 4.1 The performance of RNAscope…