Aza C Supportive care Crossover No. of patients % No. of patients % No. of patients % No. evaluated 99 92 49 CR 7 7* 0 0 5 10…
Reference Regimen Patients (no.) Median age (years) ORR (%) CR (%) OS Kantarjian et al. [19] Clofarabine monotherapy 112 71 46 38 41 weeks Faderl et al. [26]a Clofarabine +…
Fig. 12.1 The molecular mechanism of action of ATO in APL. ATO binds to the B2 domain of the PML moiety of the PML-RARα protein, inducing binding of UBC9 followed…
Author Year IO Dose No. of patients Response (%) Advani A 2010 Single 1.8 mg/m2 FL: 22 FL: 68 DLBCL:26 DLBCL: 15 Ogura M 2010 Single 1.8 mg/m2 FL: 10…
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Fig. 6.1 Treatment strategy of B-CLL by the GCLLSG. Abbreviations: FCR fludarabine, cyclophosphamide, and rituximab, BR bendamustine and rituximab, R-idelalisib rituximab and idelalisib, SCT stem cell transplantation, G-CLB obinutuzumab and…
Fig. 2.1 Morphology of cell deaths (Grasso et al. 2012) The molecular and genetic basis of apoptosis has been extensively explored. Defining programmed cell death by biochemical processes rather than…
Fig. 12.1 Structure of morphine. “Morphin – Morphine” by NEUROtiker – Own work (Licensed under Public Domain via Commons – https://commons.wikimedia.org/wiki/File:Morphin_-_Morphine.svg#/media/File:Morphin_-_Morphine.svg) 12.2.2 Oxycodone Oxycodone is a phenanthrene class opioid. Its…
Fig. 1.1 Death and survival in the United States in 2005 (Skinner 2009) Skinner’s data from 2005 had a doubling of the death rate every 8 years, just as did…
Category/year 1960 1970 1980 1990 2000 2009 2010 2012 2013 National health expenditures, in billions $27.4 $74.9 $255.8 $724.3 $1378.0 $2505.8 $2604.1 $2817.3 $2919.1 National health expenditures as percent of…
