© Springer International Publishing AG 2017Robert M. Hoffman (ed.)Patient-Derived Mouse Models of Cancer Molecular and Translational Medicinehttps://doi.org/10.1007/978-3-319-57424-0_7 7. The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung,…
Fig. 7.1 The JAK-STAT signalling pathway. Upon binding to the membrane receptors, cytokines initiate downstream signalling cascades through the JAK-STAT pathway. Cytokine receptor homodimers or heterodimers phosphorylate and activate JAKs,…
Fig. 8.1 DNA mismatch errors commonly occur at unstable genomic regions with multisatellite repeats. The repair of such DNA mismatch errors is the function of the MMR system. This process…
Fig. 3.1 Cancer vaccination and induction of T cell activation Vaccine Platforms and Vectors Common Mechanisms of Action This section will discuss various therapeutic cancer vaccine constructs, including peptide, DNA,…
Phase Regimen Patient population Results I Pembrolizumab (anti-PD-1 antibody) Advanced solid tumours, including oesophageal cancer ORR: 30.4 % (29.4 % in squamous cell carcinoma vs. 40 % in adenocarcinoma); 12-month…
• A review of 165 studies found that stress-related psychosocial factors are associated with higher cancer incidence in initially healthy populations, poorer survival in patients diagnosed with cancer (330 studies),…
1. For the Ultimate Consultation you need the Ultimate Patient to obtain the Ultimate Result 2. The Ultimate Consultation focuses on Seven Key Health Strategies 3. The Ultimate Consultation requires…
Welcome and introduction to the clinic This could be a one-pager that welcomes the patient to the clinic, provides an explanation of the philosophy of the clinic and the modalities…
