Hereditary Colorectal Cancer
White African Americans Asian American and Pacific Islander American Indian and Alaska Native Hispanic/Latino (a) Incidence Males 58.2 68.4 44.1 38.1 50 Females 42.6 51.7 33.1 30.7 35.1 (b)…
ONCOLOGY
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Fig. 18.1 Scanning electron microscopy (SEM) micrographs showing the morphology of erionite fibers, crocidolite asbestos, and chrysotile fibers. (a) Erionite f ibers from Pine Valley, NV (courtesy of Dr. Ian…
Chromosomes and Chromosomal Instability in Human Cancer
Diagnosis Cytogenetic change Molecular change Additional changes Chronic myeloid leukemia t(9;22)(q34;q11) 210KD BCR-ABL CML-AP/BP t(9;22)(q34;q11) 210KD BCR-ABL +8, +Ph, +19, i(17q), t(3;21)(q26;q22) Polycythemia vera JAK2V617F (>90%) +8, +9, del(20q),…
Biological Principles and Clinical Application of EGFR Inhibitors in Cancer
Fig. 37.1 Epidermal growth factor receptor structural and functional domains . (a) Schematic representation of EGFR sequence. L and CR, ligand-binding and cysteine-rich domains, TM transmembrane domain, TK tyrosine kinase…
Senescence, Apoptosis, and Cancer
Fig. 10.1 In cell culture systems, cellular senescence is described as a decrease in proliferative capacity and eventual cessation of proliferation with increasing number of population doublings (PDs). This property…
Beyond the Primary Tumor: Progression, Invasion, and Metastasis
Fig. 12.1 Hallmarks of cancer in the tumor progression continuum. The indicated phenotypes along the tumor progression continuum do (+), do not (−), or sometimes (+/−) involve the indicated properties…
Cancer Drug Discovery and Anticancer Drug Development
Fig. 36.1 Schematic representation of target-based drug discovery and development process . Drug discovery process typically begins with the identification and the validation of the target in vitro and in…
Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light
Fig. 24.1 Nucleotide excision repair and the DNA damage response from radiation and chemicals, oncogene driven replication and virus infections. Adapted with modifications from ref. [33]. The DDR has been…
Single Nucleotide Polymorphisms and Cancer Susceptibility
Fig. 14.1 Effect of allele frequency and relative risk on the required sample size to generate 90 % power to show significant associations (P = 0.01) for co-dominant susceptibility alleles,…
Molecular Detection and Diagnosis of Cancer
Fig. 41.1 Activating mutations in K-Ras occurring early on during pancreatic cancer development lead to higher proliferating rates of affected cells. While this may trigger the cell surveillance system that…
