© Springer Nature Singapore Pte Ltd. 2017Ranu Patni (ed.)Current Concepts in Endometrial Cancer10.1007/978-981-10-3108-3_10 10. Newer Perspectives in the Management of Endometrial Cancer Sampada Dessai1 and Anant Ramaswamy2 (1) Department of Gyn Oncology, Malabar Cancer Centre, Thalassery,…
Low risk Stage I endometrioid, grade I–II, <50 % myometrial invasion, LVSI – ve Intermediate risk Stage I endometrioid, grade I–II, > 50 % myometrial invasion, LVSI – ve High-intermediate…
Risk factors Salient features Age Peak between 55 and 70 years Race More in White race and less in Indians and South Asians Obesity BMI >30 kg/m2 Diet High in…
Fig. 5.1 RCC and AML as visualized using gray-scale ultrasonography. (a) Isoechoic lesion relative to the renal parenchyma (arrows). This lesion was surgically resected and diagnosed as an RCC. (b)…
Fig. 4.1 Gross findings of ccRCC. The tumor is whitish yellow and well circumscribed, in which degeneration and hemorrhage are observed Fig. 4.2 Microscopic findings of ccRCC. Low-grade ccRCC has…
Syndrome Gene Chromosome location Mutation rate in sporadic RCC Prevalence % de novo Renal tumor histology Multiple/solitary Penetrance of RCC Age (years) at RCC diagnosis Extrarenal manifestations VHL disease VHL…
Fig. 6.1 Treatment algorithm for nonmetastatic patients with RCC 6.2.1 Stage 1 6.2.1.1 Surgical Therapy Surgical therapy remains the mainstream treatment for patients with stage 1 RCC because the resection…
Drug Factor influencing PK PK/PD relationship PK parameter PD (efficacy, toxicity) Tyrosine kinase inhibitors Sorafenib C trough PFS Skin toxicity Hand-foot reaction Hypertension [3] AUCcum Any grade ≥ 3 toxicity…
Agent n Phase References Proleukin (IL-2) 255 Phase II Fyfe G. et al. [19] IFN-α 350 Meta-analysis Medical Research (vs medroxyprogesterone acetate) Council Renal Cancer Collaborators [22] IFN-α+ VLB 160…
Fig. 3.1 Molecular characterization of clear-cell renal cell carcinoma PBRM1 3.2.2 Mutations of Chromatin Enzymes The importance of chromatin dynamics and its dysregulation in tumorigenesis is increasingly appreciated since the…
