ONCOLOGY

Adjuvant immunotherapy in high-risk muscle invasive urothelial carcinoma: A systematic review and meta-analysis of randomized clinical trials

May 11, 2025 by in ONCOLOGY Comments Off on Adjuvant immunotherapy in high-risk muscle invasive urothelial carcinoma: A systematic review and meta-analysis of randomized clinical trials

Highlights • Initial trial results examining the efficacy of adjuvant immune checkpoint inhibitors in the setting of high-risk, resected muscle invasive urothelial carcinoma provided disparate results. • In this systematic…

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Impact of smoking exposure on disease progression in high risk and very high-risk nonmuscle invasive bladder cancer patients undergoing BCG therapy

May 11, 2025 by in ONCOLOGY Comments Off on Impact of smoking exposure on disease progression in high risk and very high-risk nonmuscle invasive bladder cancer patients undergoing BCG therapy

Highlights • High grade and very high grade NMIBC has the potential to reoccur and progress and the BCG intravesical therapy is an adjuvant gold standard treatment. • Smoking impacts…

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Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase

May 11, 2025 by in ONCOLOGY Comments Off on Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase

Highlights • The carcinogenic pathways of heavy metals/ trace elements in bladder cancer are studied. • They include alterations in MD, OS/ROS, and p38-MAPK pathway. • This data provides a…

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Retrospective analysis of partial cystectomy in patients with muscle-invasive urothelial carcinoma: A German single-center experience

May 11, 2025 by in ONCOLOGY Comments Off on Retrospective analysis of partial cystectomy in patients with muscle-invasive urothelial carcinoma: A German single-center experience

Highlights • Partial cystectomy serves as a less invasive alternative for muscle-invasive bladder cancer. • The 5-year Overall Survival rate was 55%, Cancer Specific Survival was 67%, and Recurrence-Free Survival…

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Defining the genetic profile of prostate cancer

May 11, 2025 by in ONCOLOGY Comments Off on Defining the genetic profile of prostate cancer

Highlights • Prostate cancer is associated with the genetic components. • The understanding of the genetics components of prostate cancer will help researchers in developing mitigating approach. • GWAS provides…

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Impact of postprogression therapies on overall survival: Recommendations from the 2023 kidney cancer association think tank meeting

May 11, 2025 by in ONCOLOGY Comments Off on Impact of postprogression therapies on overall survival: Recommendations from the 2023 kidney cancer association think tank meeting

Highlights • Accounting for postprogression therapies improves overall survival (OS) estimation. • Multistage treatment strategies (MTS) guide treatment sequence decisions to optimize OS. • Sequentially Multiple Assignment Randomized Trials (SMART)…

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Prospective validation of clino-radio-pathological risk scoring system (CRiSS) for prediction of inguinal lymph-nodes metastasis in squamous cell carcinoma of penis

May 11, 2025 by in ONCOLOGY Comments Off on Prospective validation of clino-radio-pathological risk scoring system (CRiSS) for prediction of inguinal lymph-nodes metastasis in squamous cell carcinoma of penis

Highlights • A prospective study to validate the diagnostic performance of CRiSS in SCC penis. • CRiSS can avoid ILND with a zero false negative rate, irrespective of cN status….

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Clinical significance of PSA dynamics in castration-sensitive prostate cancer treated with ARSI doublet therapy: A multicenter study

May 11, 2025 by in ONCOLOGY Comments Off on Clinical significance of PSA dynamics in castration-sensitive prostate cancer treated with ARSI doublet therapy: A multicenter study

Highlights • The addition of androgen receptor signaling inhibitors (ARSIs) to androgen deprivation therapy (ADT), known as ARSI doublet therapy, has shown a significant impact on PSA dynamics and oncological…

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