Megakaryopoiesis and Thrombopoiesis
SUMMARY Print Section Listen SUMMARY Each day the adult human produces approximately 1 × 1011 platelets, a level of production that can increase 10- to 20-fold in times of increased…
ONCOLOGY
Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
SUMMARY Print Section Listen SUMMARY Evaluation of a hemostatic disorder is commonly initiated when (1) a patient or referring physician suspects a bleeding tendency, (2) a bleeding tendency is discovered…
Reactive Thrombocytosis
SUMMARY Print Section Listen SUMMARY The three major pathophysiologic causes of thrombocytosis are (1) clonal, including essential (or primary) thrombocythemia and other myeloproliferative neoplasms; (2) familial, including rare cases of…
Molecular Targets and Pathways
Molecular Targets and Pathways Technological advances have paved the way for a precision treatment tailored to both patient and tumor. DNA is the key to targeted anti-cancer therapies. We want…
Targeted and Immunotherapy Agents
Targeted and Immunotherapy Agents Color Key Agents in early-stage clinical trial investigations first in man, phase 1 Agents in late-stage clinical trial investigations (phases 2 and 3) FDA-approved agents FDA-approved…
Carcinogenesis from the Perspective of Targeted Therapy and Immunotherapy
Carcinogenesis from the Perspective of Targeted Therapy and Immunotherapy Introduction In this section, we will discuss elements of cellular biology and immunology that have given insight into personalized genomically based…
Palliation
Palliation INTRODUCTION Radiation therapy (RT) can be a highly effective tool for the treatment of symptoms caused by progressive gynecologic cancers. Common indications for palliative treatment of gynecologic cancers include…
Unknown Primary
Unknown Primary INTRODUCTION Most gynecologic cancers present with bleeding, pain, or other symptoms caused by an enlarging primary tumor. However, in some cases, patients are initially diagnosed when lymphadenopathy or…
Ovarian Cancer
Ovarian Cancer INTRODUCTION As will be shown later in this chapter, there is strong evidence that radiation therapy (RT) can play an important role in the curative treatment of selected…
Targets by Organ Site
Targets by Organ Site Abbreviations • CBR: clinical benefit rate (CR + PR + SD) • CR: complete response • d: days • DOR: duration of response • HR: heart…
