Didanosine
Chapter 6 Didanosine Raphael Dolin, MD STRUCTURE Didanosine (2′,3′-dideoxyinosine, ddI, Videx, Videx EC) is a nucleoside analog active against human immunodeficiency virus type 1 (HIV-1), HIV-2, simian immunodeficiency virus, and…
INFECTIOUS DISEASE
Adrenal, Gonadal, and Thyroid Disorders
Chapter 76 Adrenal, Gonadal, and Thyroid Disorders Joan C. Lo, MD, Morris Schambelan, MD A variety of endocrine disorders have been reported in association with human immunodeficiency virus (HIV) infection…
Nelfinavir
Chapter 18 Nelfinavir Miguel A. Goicoechea, MD, Richard H. Haubrich, MD Nelfinavir (Viracept) was the fourth protease inhibitor (PI) approved by the US Food and Drug Administration (FDA) for the…
Lamivudine
Chapter 9 Lamivudine James H. Willig, MD, Joseph J. Eron, Jr, MD STRUCTURE Lamivudine (3TC, Epivir) is the negative or cis enantiomer of 2′-deoxy-3′-thiacytidine that has antiviral activity against human…
Cryptosporidia, Isospora, and Cyclospora Infections
Chapter 38 Cryptosporidia, Isospora, and Cyclospora Infections Timothy P. Flanigan, MD, Christine A. Wanke, MD It has only been since the recognition of the acquired immunodeficiency syndrome (AIDS) epidemic that…
Establishing the Diagnosis of HIV Infection
Chapter 1 Establishing the Diagnosis of HIV Infection Bernard M. Branson, MD, J. Steven McDougal, MD Treatment, especially highly active antiretroviral therapy (HAART), has dramatically improved survival for persons infected…
Occupational and Nonoccupational Exposure Management
Chapter 34 Occupational and Nonoccupational Exposure Management* Adelisa L. Panlilio, MD, MPH, Lisa A. Grohskopf, MD, MPH INTRODUCTION The primary means of preventing HIV transmission is by avoiding exposure to…
Human Herpesvirus-6 and Herpesvirus-7 Infections
Chapter 52 Human Herpesvirus-6 and Herpesvirus-7 Infections David W. Kimberlin, MD, John W. Gnann, Jr, MD In 1986 a novel virus was isolated from six patients with lymphoproliferative syndromes, two…
Pharmacogenetics of Antiretroviral Agents
Chapter 29 Pharmacogenetics of Antiretroviral Agents Catia Marzolini, PharmD, PhD, Richard Kim, MD, Amalio Telenti, MD, PhD INTRODUCTION Pharmacogenomics is an emerging clinical discipline that explores the interaction of drugs…
