Therapeutic gene editing is significant for medical advancement. Safety is intricately linked to the specificity of the editing tools used to cut at precise genomic targets. Improvements can be achieved…
Current protocols for hematopoietic stem cell (HSC) gene therapy, involving the transplantation of ex vivo lentivirus vector-transduced HSCs into myeloablated recipients, are complex and not without risk for the patient….
The clinical application and regulatory strategy of genome editing for ex vivo cell therapy is derived from the intersection of two fields of study: viral vector gene therapy trials; and clinical…
Gene therapy using autologous or allogeneic cells offers promising possibilities to treat inherited and acquired diseases, ideally leading to a long-lasting therapeutic correction. This article summarizes efforts that use integrating…
Gene delivery vectors that do not rely on host cell genome integration offer several advantages for gene transfer, chiefly the avoidance of insertional mutagenesis and position effect variegation. However, unless…
Gene therapy using hematopoietic stem cells (HSC) has developed over the past 3 decades, with progressive improvements in the efficacy and safety. Autologous transplantation of HSC modified with murine gammaretroviral…
Daniel E. Bauer, MD, PhD, Editor Related posts: In Vivo Hematopoietic Stem Cell Transduction Therapeutic Gene Editing Safety and Specificity Opening Marrow Niches in Patients Undergoing Autologous Hematopoietic Stem Cell Gene…
Fig. 7.2 Surgical resection of hepatobiliary tumors during the 30-year period in the EHBH 7.1.1.3 Pathogenesis and Mechanism Currently, it is suggested that HCC relates to the following pathogenic factors:…
Fig. 6.1 (a) The section of a huge mass is gray-red, soft, and homogeneous in texture. (b) A huge mass with a gray-green section. (c) HCA with hemorrhage. (d) Mutiple…
Fig. 9.1 Papillary adenoma: the tumor is lobulated, with slender papillae on the surface Microscopic Features According to histological morphology, gallbladder adenoma can be divided into tubular, papillary, and tubulopapillary…
