Chapter Outline HISTORIC PERSPECTIVE WHAT IS “CONSENT” IN PEDIATRICS? ASSENT IN CHILDHOOD CANCER TRIALS PEDIATRIC CLINICAL TRIALS Minimal Risk Phase I and II Trials in Pediatric Oncology Phase III Trials…
Chapter Outline EPIDEMIOLOGY ETIOLOGY CLINICAL PRESENTATION AND EVALUATION Clinical Manifestations Radiologic Evaluation Biopsy Laboratory Evaluation PATHOLOGY AND STAGING Pathology Staging NATURAL HISTORY AND PROGNOSIS Localized Disease Metastatic and Relapsed Disease…
Chapter Outline RED BLOOD CELL TRANSFUSIONS Indications for Transfusion Packed Red Blood Cells Leukoreduction of Red Blood Cells Irradiation of Red Blood Cells Immunologic Considerations Compatibility Procedures Selection of Blood…
Chapter Outline INTRODUCTION AND EPIDEMIOLOGY ORIGINS OF HEPATOBLASTOMA GENETIC PREDISPOSITION AND LIVER TUMORIGENESIS Familial Adenomatous Polyposis Overgrowth Syndromes and Hepatoblastoma Other Syndromes Genetic Syndromes and Hepatocellular Carcinoma Genetic Syndromes and…
Chapter Outline HISTORY AND OVERVIEW Recognition of Late Effects Early Mortality Identifying Risk Factors for Late Effects Interpreting Late Effects Research General Principles of Late Effects SECOND CANCERS Secondary Solid…
Chapter Outline PAIN Epidemiology Pathophysiology Assessment Approach to the Child with Pain Analgesic Medications and Interventions Adjuvant Treatments Invasive Approaches to Pain Management Psychological and Nonpharmacologic Approaches to Pain Pediatric…
Chapter Outline CONCEPTUAL MODELS GUIDING THE PSYCHOSOCIAL CARE OF CHILDREN AND FAMILIES PROFESSIONAL ROLES AND A TEAM APPROACH TO PSYCHOSOCIAL CARE CRISIS OF A CANCER DIAGNOSIS Presenting the Diagnosis and…
Chapter Outline TYPES OF DENDRITIC CELLS ORIGINS OF DENDRITIC CELLS LANGERHANS CELL HISTIOCYTOSIS Incidence Clinical Features Management Refractory Langerhans Cell Histiocytosis Reactivation Long-Term Consequences Overview of Therapeutic Options NON–LANGERHANS CELL…
Chapter Outline EPIDEMIOLOGY BIOLOGIC FEATURES Chromosomal Rearrangements in Ewing Sarcoma The Cloning of EWS/FLI EWS/FLI and Other TET/ETS Fusions in Ewing Sarcoma Ewing Sarcoma Cell of Origin EWS/FLI Target Genes…
Chapter Outline INTEGRATING PALLIATIVE CARE FROM THE TIME OF DIAGNOSIS Advantages of Early Integration of Palliative Care Enhancing Integration of Palliative Care When Cure is No Longer Possible MAKING THE…
