Abstract This chapter describes the current understanding of a wide variety of platelet pathology, including thrombocytopenia, thrombocytosis, qualitative platelet disorders, and diagnostic approaches to these problems. Autoimmune and alloimmune neonatal…
Abstract This chapter describes the clinical manifestations, diagnosis, complications, and management of sickle cell disease, thalassemia, and other hemoglobinopathies. Keywords Sickle cell disease, thalassemia, anemia, transcranial Doppler ultrasonography, transfusion, chelation…
Abstract The term polycythemia, particularly as it pertains to newborns and children, should be more accurately termed erythrocytosis because it generally refers to conditions in which only erythrocytes are increased…
Abstract This chapter focuses on hemolytic anemia caused by extracorpuscular defects due to immune-mediated hemolytic anemia caused by warm and cold antibodies and nonimmune red cell destruction from acquired and…
Abstract Megaloblastic anemias are characterized by the presence of megaloblasts in the bone marrow and macrocytes in the blood. In more than 95% of cases, megaloblastic anemia is a result…
Abstract This chapter describes the causes, clinical manifestations, diagnosis and treatment of various types of both acquired and inherited bone marrow failure syndromes. Keywords Diamond–Blackfan anemia (DBA), Fanconi anemia (FA),…
Abstract Iron deficiency is the most common nutritional deficiency in children and is worldwide in distribution, affecting 2 billion people. The prevalence of iron deficiency worldwide is twice as high…
Abstract Anemia during the neonatal period is caused by: (i) Hemorrhage : acute or chronic, (ii) Hemolysis : congenital hemolytic anemias or due to isoimmunisation, and (iii) Failure of red…
Abstract Lymphadenopathy and splenomegaly are common findings in children. Both benign and malignant processes can produce these findings and it is important to distinguish between the two so that appropriate…
Abstract Anemia can be defined as a reduction in hemoglobin concentration, hematocrit, or number of red blood cells per cubic millimeter. The lower limit of the normal range is set…
