Late menarche, giving birth, breastfeeding, oral contraceptive use, IUD use, and tubal ligation decrease risk for both endometrial and ovarian cancer, while more ovulatory cycles, obesity, use of talc in…
Hereditary cancer syndromes are responsible for 5% of endometrial cancers and 10% of ovarian cancers. Hereditary breast and ovarian cancer syndrome and Lynch syndrome account for most of these inherited…
Ross S. Berkowitz, MD, Guest Editor Like many areas in oncology, gynecologic oncology has made several important recent advances in both the prevention and the treatment of reproductive malignancies. New…
Evaluation and treatment of hematologic disorders in pregnancy requires an understanding of normal physiologic changes during pregnancy. Hematologic disorders may be caused by preexisting conditions, normal physiologic changes, or can…
The diagnosis and management of severe thrombocytopenias can be difficult, but is necessary to avoid significant morbidity and mortality. The causes of severe thrombocytopenias, often with a platelet count of…
This article gives a general overview of venous thromboembolism (VTE). Pathophysiology, presentation, diagnosis, and initial management of VTE are briefly reviewed. More difficult management problems are reviewed in greater depth,…
Lymph node or spleen enlargement may be innocent or the first sign of a serious disorder. Lymphadenopathy and splenomegaly can be found in symptomatic or asymptomatic patients. Lymph node enlargement…
A monoclonal spike on serum protein electrophoresis is a frequent finding in the general population and pathognomonic of a plasma cell dyscrasia. In otherwise healthy individuals, it is diagnostic of…
Thrombocytosis is a common clinical problem frequently encountered during routine evaluation. The diagnostic workup entails a step-by-step approach, which allows for an accurate assessment of the underlying cause. A thorough…
The evaluation of a patient presenting with bleeding symptoms is challenging. Bleeding symptoms are frequently reported by a normal population, and overlap significantly with bleeding disorders, such as type 1…
