Primary POF Genetic aberrations X-linked (monosomy, trisomy, deletions, translocations, fragile X) Autosomal dominant (FSH receptor gene polymorphism, inhibin B mutation, etc.) Enzyme deficiency Metabolic Autoimmune disease Secondary POF Surgical Bilateral…
© International Society of Gynecological Endocrinology 2017Charles Sultan and Andrea R. Genazzani (eds.)Frontiers in Gynecological EndocrinologyISGE Series10.1007/978-3-319-41433-1_10 10. The Long-Term Cardiovascular Risks Associated with Amenorrhea Tommaso Simoncini1 , Andrea Giannini1 and Andrea R. Genazzani1 (1) Division of Obstetrics and Gynecology,…
Characteristics Functional Hypothalamic Amenorrhoea (FHA) Anorexia nervosa (AN) Body weight Normal or low Very low to normal Body fat Normal or low Very low to normal Intake of calories or…
© International Society of Gynecological Endocrinology 2017Charles Sultan and Andrea R. Genazzani (eds.)Frontiers in Gynecological EndocrinologyISGE Series10.1007/978-3-319-41433-1_8 8. Functional Hypothalamic Amenorrhea as Stress Induced Defensive System Alessandro D. Genazzani1 , Giulia Despini1, Riccardo Bonacini1 and Alessia Prati1 (1) Center for Gynecological…
POI risk level Gonadotoxic drugs High Busulfan, chlorambucil, chlormethine, cyclophosphamide, ifosfamide, melphalan, procarbazine Medium Adriamycin, carboplatin, cisplatin, docetaxel, doxorubicin, paclitaxel Low Bleomycin, dactinomycin, 5-Fluoruracil, mercaptopurine, methotrexate, vinblastine, vincristine Oocytes are…
Cause Symptoms and signs Evaluation Due to a CNS lesion Hypothalamic hamartoma May be associated with gelastic (laughing attacks), focal or tonic-clonic seizures. MRI: Mass in the floor of…
and Rachel Livingstone2 (1) Glasgow Royal Infirmary, Glasgow, UK (2) Specialty Trainee, Royal Alexandria Hospital, Paisley, UK 2.1 Mode of Action and Clinical Pharmacology Sodium-glucose cotransporter-2 (SGLT2) inhibitors have a…
(1) Glasgow Royal Infirmary, Glasgow, UK 3.1 Introduction Evidence-based clinical practice guidelines are systematically developed statements intended to assist practitioners and patients about making and understanding care decisions for…
Figure 1.1 Global prevalence of diabetes (Reproduced with permission from the International Diabetes Federation [1] ©IDF) 1.2 Diagnostic Criteria for Diabetes The diagnostic criteria from the World Health Organization (WHO)…
(1) Glasgow Royal Infirmary, Glasgow, UK 4.1 Introduction Type 2 diabetes is becoming a common problem in young obese people and, in some parts of the world, is as…
